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| The clinical effect of progynova combined with progesterone to prevent intrauterine adhesion of patients with missed abortion after uterine curettage |
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Abstract Objective: To analyze the effect of progynova combined with progesterone to prevent intrauterine adhesions of patients with missed abortion after uterine curettage. Method：One hundred and four patients with missed abortion were recruited and divided into the observation group (52 cases) and the control group ( 51 cases). Patients in control group were not given any medication after uterine curettage, while patients in observation group took progynova (2 mg, once a day) for 5 days and progesterone capsules (50 mg, once a day) for 3 weeks after curettage. The bleeding duration and bleed volume, the duration and the degree of abdominal pain, the change of menstrual and the rate of intrauterine adhesion were observed in both groups. Result: Compare to control group, bleeding volume, duration of bleeding or abdominal pain was significant lower (t=4.615, 5.037, 10.620, P<0.01). In observation group, most of the patients were mild abdominal pain, and the degree of pain was significant lower (χ2=7.890, P<0.05). The rate of hypomenorrhea and amenorrhea was also lower in observation group significantly (χ2=6.272, P<0.05) and the time of menses recovery was shorter (t=6.537, P<0.01). The incidence of intrauterine adhesions was significantly lower (χ2 =4.039, P<0.05). Conclusion: Using progesterone combined with progynova can effectively prevent intrauterine adhesions in patients with missed abortion after uterine curettage.
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