Objective: To evaluate the contraceptive efficacy of medicated GyneFix intrauterine device (IUD) when compared with other common IUDs. Methods: We searched medical databases including CNKI (19792014), CBMdisc (19782014), Wanfang Database (19822014), VIP Database (19892014) by computer. And we screened randomized control trials and then performed the metaanalysis by using RevMan5.0 software. Results: Fifteen articles from 580 literature were recruited for metaanalysis according to the inclusion and exclusion criteria. The rate of pregnancy with IUD in situ of medicated GyneFix IUD was lower than that of Yuangong copper 220 IUD when followed up at 12th month ［odd ratio (OR)=0.19 (95% confidence intervals (CI 0.080.47)］. And the rate of pregnancy with IUD in situ of medicated GyneFix IUD was lower than that of copper T220C IUD when followed up at 6th,12th month ［OR=0.18 (95%CI 0.050.68), 0.13 (95%CI 0.050.37), respectively］. The expulsion rate of medicated GyneFix IUD was lower than that of Yuangong cooper 220 IUD when followed up at 12th, 24th month ［OR=0.24 (95%CI 0.100.59), 0.09 (95%CI 0.020.39), respectively］. And the expulsion rate of medicated GyneFix IUD was lower than those of copper T380A IUD ［OR=0.17 (95%CI 0.040.76)］ and copper T220C IUD ［OR=0.21 (95%CI 0.080.55)］ when followed up at 12th month. The removal rate for medical reason of medicated GyneFix IUD was lower than that of Yuangong copper 220 IUD when followed up at 6th,12th month ［OR=0.39 (95%CI 0.200.77), 0.21 (95%CI 0.120.36), respectively］. The removal rate for medical reason of medicated GyneFix IUD was lower than that of copper T380A IUD when followed up at 3th, 6th,12th month ［OR=0.21 (95%CI 0.070.65), 0.11 (95%CI 0.040.31), 0.09 (95%CI 0030.23), respectively］. And the removal rate for medical reason of medicated GyneFix IUD was lower than that of copper T220C IUD when followed up at 6th,12th month ［OR=0.22 (95%CI 0.070.66), 0.23 (95%CI 0.110.48), respectively］. Conclusion: Medicated GyneFix can prevent the pregnancy effectively and reduce the expulsion rate and the removal rate for medical reason. So it has the favorable contraceptive efficacy and is worth using widely.