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| Clinical effect of mifepristone and misoprostol combined with rivanol in mid-trimester induction of labor |
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Abstract Objective: To explore the clinical effect of mifepristone and misoprostol combined with rivanol in mid-trimester induction of labor in order to find a safer and more effective method of induced labor. Methods: A total of 120 patients applying for induction of labor were assigned into observation group (n=60) and control group (n=60) according to their informed choices. Intra-amniotic injection of 100 mg rivanol was conducted in the control group as well as the observation group. Women in the observation group were received 150 mg of mifepristone orally prior to the injection, and were inserted 200 g of misoprostol in posterior vaginal fornix after 24 hours. Results: The average onset time of contraction, total stage of labor and amount of postpartum hemorrhage of the observation group were obviously less than those of the control group (P all＜0.05). Birth canal damage was found in two women in the observation group and three in the control group, showing no significant difference between the two groups (P>0.05). Conclusion: Mifepristone and misoprostol combined with rivanol could obviously shorten the duration of induced labor with no serious adverse reaction.
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