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Abstract Objective: To explore the status of the infection of Toxoplasma gondi (TOX), rubella virus (RV) and cytomegalovirus (CMV) among women of childbearing age in Nanchang to prevent the birth defect caused by the infection mentioned above. Methods: The clinical data, the positive rate and influential factors of TOX, RV and CMV infection from 15 879 women who once got preconception detection of antibody against TOX, RV and CMV in Reproductive Health Care Center of Jiangxi, Education Service Center of Nanchang Population Family Planning Commission and other sites were retrospectively analyzed. Results: Among women of childbearing age in Nanchang, the positive rate of TOX-IgM was 4.20%, the positive rate of TOX-IgG was 5.50%, the positive rate of RV-IgG was 96.70%, the positive rate of of CMV-IgM was 6.50%, and the positive rate of CMV-IgG was 95.20%. The residence place, season, history of animal contact and abnormal history of pregnancy were the important factors to influence the infection rate of three pathogens (Pall <0.05). Conclusion: According to infection characteristics of the three pathogenic microorganism, rural women should be listed as the main screening population, and the women with adverse pregnancy history should be coupled with more eugenics guidance. Furthermore, more public education for all women should be promoted. The pregnant women should take more care during the first trimester in order to reduce birth defects.
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