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| Clinical effectiveness of Yuangong copper 300, copper T 380A and medicated copper ring 165 intrauterine devices |
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Abstract Objective: To observe the clinical effectiveness of Yuangong copper 300 (YGCu300), copper T 380A (TCu380A) and medicated copper ring 165 (MCR165) intrauterine devices (IUDs), and to explore the way to improve their use. Methods: A randomized, comparative, multi-centre clinical trial was performed between July 3, 2007 and November 21, 2008. Totally 3299 eligible women were recruited and administered three types of IUDs randomly during their intermenstrum. Results: Among the 3299 women, 8(0.24%) were excluded because of uncompleted the first year-follow up. There were 1104, 1104 and 1091 cases were inserted YGCu300, TCu380A and MCR165 IUDs, respectively. By the end of the first year, the pregnancy with IUD in situ among three groups were no significantly differences (P＞0.05). The discontinuation rates of all expulsion of the three groups were similar(P＞0.05). The rate of the total expulsion of MCR165 IUD (2.09 per hundred women year) was the highest, and there was significant difference between it and YGCu300 (0.84 per hundred women year) and TCu380A IUDs (0.75 per hundred women year) respectively (P＜0.05). Four cases of unwanted pregnancy were found in the group of MCR165 IUD. The medical removal rate for bleeding/pain of three types of IUDs were 4.67 per hundred women year, 2.61 per hundred women year and 1.61 per hundred women year, showing significant differences among three groups (P＜0.05). Conclusion: The three types of IUDs have different advantages and shortcomings. We should choose IUD for women according to their situation and the characteristic of IUD, and to improve the actual value of IUD in use.
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