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LIN Jie, CHEN Ying, LI Ying
Objective: To evaluate the association between pregnancy rate of TCu220C IUD and its influence factors , and to compare pregnancy rate of TCu220C and other copper-bearing IUDs, and to assess the effectiveness of TCu220C IUD. Methods: 9 electronic databases (PubMed, EMBASE, CENTRAL, etc.) and several related websites (ClinicalTrials, Current Controlled MetaRegister, Chinese clinical trial registry, WHO, FDA, Bayer, Wyeth) were searched. Software of Open Meta-analyst and RevMan5.3.3 were used to analysis and incorporate of data. Results: 7726 Chinese and English literatures were searched preliminarily, but only 31 RCTs and quasi RCTs of TCu220C IUD were recruited for further analysis according to the inclusion and exclusion criteria. The results showed that：①The pregnancy rate of TCu220C in China was higher than that of other countries in the first and second year follow-up after IUD inserted, but it was very similar in the 10th year follow-up. There was no significant difference in pregnancy rates of TCu220C between that in China and in other countries（P>0.05）.②There was no significant difference in pregnancy rates of TCu220C when comparing insertion after spontaneous abortion to lactation period abortion. ③There was no significant difference in pregnancy rates of TCu220C among different age women.④The pregnancy rate of TCu220C was significantly lower than that of MLCu250 at the time of 2 years follow-up, and also was lower than that of Stainless Steel Ring at the time of 1 and 2 years follow-up. While pregnancy rates of TCu220C compared to active-165, MCuⅡ, active-γ, MCu, VCu, Uterine-shaped copper 300, MLCu375, or TCu380A, there was no significant difference. Conclusion: This meta -analysis is the first time to explore the association between the pregnancy rate of TCu220C and its influence factors. The result showed that the pregnancy rate of TCu220C was not affected by used in different country, IUD inserting time, or age of woman. There was no any evidence implied pregnancy rate of IUDs associated with copper surface area, so more researches should be conducted to further confirmed that.
2015 Vol. 23 (12): 796- [Abstract]（
87
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XIONG XiaoJuan, CAO QiaoChun, ZHANG Jing, et al
Objective: To analysis the effectiveness and cost of different treatment for cesarean scar pregnancy (CSP) .Methods: From November 2011 to September 2014, 69 patients with CSP in Jiujiang Maternal and Children Health Care Hospital were divided into 3 groups: 13 cases in dilatation and curettage (D and C) group; 20 cases in Methotrexate (MTX) group: MTX+ Calcium Folinate (CF) + D and C; 36 cases in Bilateral Uterine Artery Chemotherapy Embolism (BUACE) group: (BUACE + D and C). The effectiveness and costs of three treatments were compared. Results: (1) The treatment in the three groups all had excellent effectiveness. In D and C group, 2 cases had further treated by BUACE, 1 case had experienced abdominal subtotal hysterectomy because of heavy bleeding, and 2 cases had further treated by MTX + CF. In MTX group, 1 case had further treated by BUACE , and 1 case had been operated of transabdominal scar lesion resection. There was no any case had shocked in BUACE group. Comparing to D and C group or MTX group, the patients in BUACE group were less bleeding and needed less blood transfusion, the hospitalization time was shorter, blood HCG had dropped quicker, which had statistically significant differences (P<0.01). But in the 3 groups, incidence of shock and other adverse events, menstruation recovery time and return to work time were similar, there was no statistical difference (P> 0.05). (2) Comparing to D and C group and MTX group, though BUACE group had the higher cost of hospitalization expenses, the loss of working time and transportation costs were less, which had statistical significant difference (P< 0.01). The total cost and loss of working time had no statistical difference (P > 0.05) among the three groups. Conclusion: BUACE combined with D and C to treat CSP is safe and effective. The total cost is not higher than other treatments.
2015 Vol. 23 (12): 802- [Abstract]（
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LIN Xia
Objective: To know the current situation and training demand of family planning technical service staffs from municipalities and counties in Heilongjiang province. And to provide evidence for training plan. Methods: This study was a quantitative stratified cluster sampling investigation. In October 2014, a questionnaire survey was conducted among 505 family planning technical service staffs from family planning technical service stations of municipalities and counties in Heilongjiang province. Results: 6.6% technical staff in the survey was under the age of 30, and some staffs had not obtained relevant qualification certificate in different post of duty. In recent three years, the training rate among stuffs was 57%. The training rate of technical staff was different based on their different professional title or different jobs. 97.7% technical staff believed that it was necessary to be trained, and 8.1% technical staff believed that training in the past had helped them to pass the exam of professional title. The most common training form which had completed was special lecture, but the staff would like to clinical practice training in the future. And they also hoped to be trained about diagnosis and treatment of gynecological diseases. The technical staffs thought that past training time was too short and lacked of practice training. Conclusion: The survey indicated that lack of enough younger technical staffs to accept training was a problem. The rate of training was too low in the past training, and the past training had little help for improving professional title. The staffs ask for more training, and they hope the training form should be different from special lecture. The training administrator should pay more attention to technical training on appropriate training forms, enough training time, and appropriate training content. Special training for promote professional title and medical licensing examination should be organized more.
2015 Vol. 23 (12): 806- [Abstract]（
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HUANG Fang
Objective: To explore the clinical effect of carboprost tromethamine to prevent abnormal hemorrhage of scar uterine cesarean delivery and cost. Methods: The study was a prospective controlled clinical trial. 241women experienced scar uterine cesarean delivery were divided randomized into two groups , 126 women was in carboprost tromethamine(CT) injection group and 115 women was in saline injection group. The amount of bleeding during and after operation, rate of postpartum hemorrhage，rate of blood transfusion, total hospitalization expense and human resource cost were compared in the two groups. Results: When compared to saline injection group, amount of bleeding during and after operation, rate of postpartum hemorrhage，and rate of blood transfusion were all much less in injection CT group (P<0.05). Though total hospitalization expense in CT injection group was same as in saline injection group (P>0.05), cost of drug and nursing were less. Furthermore, time of operation ,time of hospitalization and downtime of family members were all shorter (P<0.05).Conclusion: Carboprost tromethamine can reduce the amount of bleeding during and after operation of women with scar uterine cesarean delivery, and it do not increase total hospitalization expense.
2015 Vol. 23 (12): 811- [Abstract]（
66
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LI Jiawei, NIU Jianmin, ZHOU Ping, et al
Objective: To explore the characteristic of glucolipid metabolism and pregnancy outcome in women with intrahepatic cholestasis of pregnancy(ICP). Methods: Total 86 women with ICP were recruited, who visited Guangdong Maternal and Child health Hospital for maternity and child care and delivery. The two observation groups included 30 women with early-onset ICP or 56 women with late-onset ICP, respectively. Another 60 normal pregnant women in the same period were in the control group. Pregnancy outcome and serum levels of glucose and lipid metabolism were compared among the three groups. Results: Levels of fasting blood-glucose(FPG), fasting insulin(FINS), triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C) and apolipoprotein B(ApoB) of women in control groups were all higher than those of women in control group, but levels of the high density lipoprotein cholesterol(HDL-C), apolipoprotein A(ApoA) and ApoA/ApoB were lower than those of women in control group, the differences were statistically significant(P <0.05). Compared with normal pregnant women, the incidences of cesarean section, preterm birth, meconium-stained fluid, postpartum bleeding volume and asphyxia neonatorum were higher, but the gestational weeks when delivery and neonate birth weight were lower, the differences were statistically significant(P <0.05). The levels of FPG, FINS, TG, TC, LDL-C and ApoB of women with the early-onset ICP were significantly higher than those of women with the late-onset ICP (P <0.05).The incidences of preterm birth, meconium-stained fluid and asphyxia neonatorum of women with the early-onset ICP were significantly higher than those of women with the late-onset ICP (P <0.05), but neonate birth weight was significantly lower (P <0.05). Conclusion: The levels of glucose and lipid metabolism in pregnant women with ICP may reflect the gravity of disease. As these changes appear earlier in pregnant, adverse pregnancy outcome would be heavier, which should be paid more attention to.
2015 Vol. 23 (12): 815- [Abstract]（
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WANG yan，LING Yuan, HUANG Hailong，et al
Objective: To explore the prevalence of Microdeletions in azoospermia factor(AZF) region on Y chromosome in infertile men, and to determine the correlation between subtypes of AZF and clinical phenotype. Methods: Multiplex PCR was used to detect sequence tagged sites(STS) of AZF microdeletions in 1700 infertile men .Results: The total prevalence of microdeletions was 6.59%（112/1700）. AZFc deletion in the total loss accounted for 67.86% (76/112), 35 cases had no sperm, 31 cases had oligospermia. Among the patients with no sperm, AZFb+c+sY145 deletion was 17.86%（20/112）,AZFa deletion was 4.46%（5/112），AZFa+b+c deletion was 4.46%（5/112）, AZFb+c deletion was 2.68%（3/112），AZFb+c +sY84（AZFa）deletion was 1.79%（2/112）; AZFc and sY143（AZFb）deletion was 0.89%（1/112）. Conclusion:Patients with absence of AZFc had multiple manifestations. Patients with absence of AZFa and AZFb all had no sperm, so it is necessary to screen microdeletion of AZF on Y chromosome for the patients with idiopathic infertility, especially for the infertility patients fitting line of assisted reproductive technology to help pregnant.
2015 Vol. 23 (12): 816- [Abstract]（
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