Objective: To evaluate the association between pregnancy rate of TCu220C IUD and its influence factors , and to compare pregnancy rate of TCu220C and other copper-bearing IUDs, and to assess the effectiveness of TCu220C IUD. Methods: 9 electronic databases (PubMed, EMBASE, CENTRAL, etc.) and several related websites (ClinicalTrials, Current Controlled MetaRegister, Chinese clinical trial registry, WHO, FDA, Bayer, Wyeth) were searched. Software of Open Meta-analyst and RevMan5.3.3 were used to analysis and incorporate of data. Results: 7726 Chinese and English literatures were searched preliminarily, but only 31 RCTs and quasi RCTs of TCu220C IUD were recruited for further analysis according to the inclusion and exclusion criteria. The results showed that：①The pregnancy rate of TCu220C in China was higher than that of other countries in the first and second year follow-up after IUD inserted, but it was very similar in the 10th year follow-up. There was no significant difference in pregnancy rates of TCu220C between that in China and in other countries（P>0.05）.②There was no significant difference in pregnancy rates of TCu220C when comparing insertion after spontaneous abortion to lactation period abortion. ③There was no significant difference in pregnancy rates of TCu220C among different age women.④The pregnancy rate of TCu220C was significantly lower than that of MLCu250 at the time of 2 years follow-up, and also was lower than that of Stainless Steel Ring at the time of 1 and 2 years follow-up. While pregnancy rates of TCu220C compared to active-165, MCuⅡ, active-γ, MCu, VCu, Uterine-shaped copper 300, MLCu375, or TCu380A, there was no significant difference. Conclusion: This meta -analysis is the first time to explore the association between the pregnancy rate of TCu220C and its influence factors. The result showed that the pregnancy rate of TCu220C was not affected by used in different country, IUD inserting time, or age of woman. There was no any evidence implied pregnancy rate of IUDs associated with copper surface area, so more researches should be conducted to further confirmed that.