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LI Ying, TANG Shaowen, SUN Zhiming, et al
Objective: To evaluate the safety and efficacy of TCu220C intrauterine device (IUD), and to compare the effect of TCu220C with other copper bearing IUDs for providing scientific evidence for safe contraception. Method: English databases including PubMed, EMBASE, CENTRAL, POPLINE, websites including Current Controlled metaRegister, FDA, WHO and related enterprises, and Chinese databases including CBMdisc, CMCI, CNKI, VIP and Wanfang were searched. The inclusion and exclusion criteria were set according to the PICOS principle. The literatures were imported into the endnote X7 software of document management, and repeat literatures in the database were excluded. The data was inputted by EpiData 3.1, and pool trial proportion with weight and derive RR and 95% confidence interval of meta-analysis was conducted by RevMan 5.3.3 and OpenMeta Analyst. The criteria on assessing risk of bias were used for methodological quality of literatures. The GRADE system was used for grading of evidence quality. Search results: 7097 Chinese and 629 English literatures were preliminarily retrieved, 28 studies involving TCu220C IUD RCTs and quasi RCTs ultimately were recruited, including 31 literatures formally published from 1983 to 2014, which was 7 English and 24 Chinese literatures. There were a total of 43239 women, including 15794 IUD users in TCu220C group and 27445 IUD users in control group (using other IUD). Results: Comparing overall effect of domestic group with abroad group in TCu220C IUD users, there were significant differences of the total termination rate, using related discontinuation rate, termination rate for medical reason removal, side effects rate, while no significant differences of pregnancy rate and expulsion rate. Meta analysis results also showed that the risk of expulsion of TCu220C IUD inserted after artificial abortion increased. The risk of medical removal of TCu220C IUD inserted after artificial abortion or lactation significantly increased (mainly for bleeding and pain). Conclusions: Although the use of the TCu220C IUD is affected by the inserted periods and the different users, it is still selectively used among the appropriate women.
2015 Vol. 23 (11): 724- [Abstract]（
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XING Baoheng, CAO Yalei, DONG Xiujuan,et al
Objective: To investigate the effects of resveratrol regulating lipid metabolism disorder of rats with gestational diabetes. Methods: 60 rats with gestation for five days were intraperitoneal injected streptozotocin(STZ) 35mg/kg to make gestational diabetic model. All of the rats were randomly divided into five groups and there were 12 rats in each group, which including no any treated gestational diabetic model control group, resveratrol(60, 120 or 240 mg/kg) treated groups and Metformin hydrochloride 200 mg/kg treated group. Except that, 12 rats with gestation for five days into normal gestation control group and 12 non-pregnant rats into another control group. The level of plasma glucose and insulin were determined before the drugs treatment and 7, 14 days after treatment. After two weeks of treatment, the body weight was detected , the content of TC, TG, LDL C, HDL C in serum were detected, and the level of Leptin, Adiponectin, Chemerin, TNFα, IL6 in plasma were also detected. Results: Compared with normal pregnant rats, the level of plasma glucose of rats and the body weight of rats in gestational diabetic model group were significantly increased and the level of insulin was significantly decreased；the level of TC, TG, LDL C were significantly increased and the HDL C was significantly decreased; the level of Leptin, Chemerin, TNFα, IL6 in plasma were significantly increased and the Adiponectin was significantly decreased. Compared with the rats with gestational diabetic in no resveratrol treated group, the content of TC and TG, the level of plasma glucose, the content of LDL C, the level of Leptin, Chemerin, TNFα, IL6 in plasma and the body weight of rats in resveratrol treated groups were significantly decreased, but the level of insulin, the content of HDL C and the level of Adiponectin in plasma were significantly increased. And all of above changes complied with dose dependent of resveratrol. Compared with the Metformin hydrochloride treated group, the level of insulin and the Adiponectin of rats in resveratrol 240 mg/kg treated group was significantly increased, the content of TC, TG, LDL C were significantly decreased, and the level of Leptin, Chemerin, TNFα,and IL6 in plasma were also significantly decreased. Conclusion: Resveratrol improves insulin secretion, lowering blood sugar and body weight of rats, and can regulate plasma lipid, Leptin, Chemerin, TNFα, IL6 and Adiponectin, which is a dose-dependent effect. Resveratrol 240 mg/kg treatment has higher effectiveness than that of Metformin hydrochloride treatment.
2015 Vol. 23 (11): 733- [Abstract]（
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TANG Jun, LIU Chuan, DU Wei, et al
Objective: To explore the role of endoplasmic reticulum stress (ER stress) in ovarian cancer cell apoptosis induced by MG132. Methods: SKOV3, A2870 and CAOV3 ovarian cancer cells were divided into control group and different proteasome inhibitor-treated groups; SKOV3 cells were divided randomly into GRP78 small interfering RNA (siRNA) group or random sequence of nucleic acids siRNA group. The three species ovarian cancer cells were treated with proteasome inhibitor MG132(5 nmol/L), PSI（20 nmol/L）or EPOX（10 nmol/L）, respectively. GRP78 mRNA protein expression levels in different cells were analyzed by real time quantitative PCR and Western blot. Cell viability and apoptotic cells were measured by MTT assay and flow cytometry. Results: Proteasome inhibitors increased GRP78 mRNA and protein expression levels. As expression of GRP78 siRNA targeting inducted by GRP78, SKOV3 cell vitality significantly decreased after proteasome inhibitor effection. Conclusion: Inducing GRP78 expression disturbs activity of proteasome inhibitors on resistanting ovarian cancer. Expression of GRP78 might enhance the antitumoral efficacy of proteasome inhibitors on ovarian cancer cells.
2015 Vol. 23 (11): 739- [Abstract]（
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KE Yu, HUANG Ying, ZHANG Zhiping, et al
Objective: To explore the influencing factors on induced abortion of hospital based women of childbearing age. Methods: A cross sectional survey was conducted in women of childbearing age who visited Pu Dong or Pu Tuo Maternal and Child Care Hospital for antenatal examination. A self administered and anonymous questionnaire was used to collect information on women's knowledge, attitude, and practice (KAP) on induced abortion. Results：A total of 3303 questionnaires were eligible. The proportion of these women who had ever experienced induced abortion was about 34.71%. According to the analysis of contraceptives using in the women, 86.67% women with using implants never experienced any induced abortion, and it was the highest; the second was Depot medroxyprogesterone (DMPA) users, 71.43% women hadn't experienced any induced abortion with using DMPA. But women who had intrauterine devices inserted had the highest induced abortion rate, which was 69.34%; the second was emergency pill users, whose induced abortion rate was 54.55%. The analysis of logistic regression showed that influencing factors on induced abortion were age, education attainment, family income, household registration, age at first coitus, age at first contraception using and number of children. Conclusion: Induced abortion ratio is high in women of childbearing age of Shanghai. The proportion of induced abortion in women is Not only influenced by contraceptives, but also influenced by social economic and personal status.
2015 Vol. 23 (11): 743- [Abstract]（
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TANG Yuanhong, JING Lipeng, HUANG Weihuang, et al
Objective: To analyze the situation of human papilloma virus (HPV) infection in urban women of YangJiang and its genotype distribution. Method: From April 2013 to October 2013, cervical exfoliated cell of 3852 urban women were collected and 16 different kinds of HPV genotypes were detected by SELDI TOF MS technique. Result: the mean age of these women was 40.05±7.61years. HPV infection was found in165 women, and the infection rate was 4.3%, the rate of multiple HPV infection was 11.5%. The HPV infection rate in women under of 35 years，35~44 years women，45~54 years women，and older than 55 years was 5.7%, 3.8%, 3.6%, and 4.4%, respectively, there were no statists difference among different age groups. The distribution characteristics of women with HPV infection was twin peaks liked"V". Conclusion:The HPV infection was low in YangJiang region, which mainly caused by single HPV genotypes. The most prevalent genotype in YangJiang was HPV52, followed by HPV16, HPV18 and HPV58.
2015 Vol. 23 (11): 748- [Abstract]（
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SUO Jing, ZHANG Ruying
Objective: To explore the influence of two kind hemostasis on ovarian reserve function in laparoscopic ovarian cyst resection. The method of hemostasis included electro coagulation and suture. Method：80 patients experienced laparoscopic ovarian cyst resection were recruited，and were divided randomly into 40 cases in the electric coagulation hemostasis group and 40 cases in the suture hemostasis group. In order to evaluate the ovarian reserve function after operation, the change of serum follicle stimulating hormone（FSH）, luteinizing hormone（LH）, estradiol（E2） and the number of antral follicle（AFC）, ovarian artery peak systolic velocity（PSV）were detected in the two groups preoperative and postoperative 6 months. Result：Compared to preoperative, the levels of FSH and LH increased after 6 months of operation in Electric coagulation hemostasis group, and level of E2, AFC, PSV declined, and there were statistical difference (P<0.05). However, there was no any change compared preoperative with postoperative in the suture hemostasis group. Conclusion：Electric coagulation hemostasis maybe influence on the ovarian reserve function heavily, but suture hemostasis has less influence on the ovarian reserve function.
2015 Vol. 23 (11): 752- [Abstract]（
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GAO Weiwei
Objective: To explore the clinical effect of lymphocyte active immunotherapy on repeated spontaneous abortion women with blocking antibody negative. Methods: From January to June 2012, 149 patients with repeated spontaneous abortion were recruited, whose blocking antibody negative was confirmed and received the active immune therapy in Ankang traditional Chinese medicine hospital. The peripheral venous blood of the patients 'husband was regarded as the target antigen, and performed the active lymphocyte immune therapy. Meanwhile, the repeated spontaneous abortion women who never experienced any immune therapy were included in control group. The lymphocyte factor expression was detected and pregnancy outcome was observed. Results: The study showed that the rate of pregnancy in trial group and in control group was 42.1% and 21.6%, respectively, and there was statistically significant difference (P < 0.05). The rate of spontaneous abortion again was 25.0%, 58.3%, respectively, and there was statistically significant difference (P < 0.05). After active immunotherapy, the level of lymphocyte factor (IL-2, IFN-gamma, IL-4, IL-6) and the effectives of blocking the CD4+and CD8 + were significantly higher than those of control group (P< 0.05). After immunotherapy, the level of lymphocyte factor expression (IL-2, IFN-gamma, IL-4, IL-6) in blocking antibody positive patients were significantly higher than that of blocking antibody negative patients (P < 0.05), and numbers of CD4 + and CD8 + were significantly higher in the blocking antibody positive patients, and there was statistically significant difference (P< 0.05). Conclusion: The active immunotherapy can improve pregnancy rate, reduce the risk of spontaneous abortion. The effective of immunotherapy of repeated spontaneous abortion patients with blocking antibody negative is remarkable, and the efficiency of clinical treatment is reliable.
2015 Vol. 23 (11): 755- [Abstract]（
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CAI Dili, CHEN Zhiqin, ZHU Danyang, et al
Objective: To explore the effects of different promoting cervical mature and induced labor methods for patients with premature rupture of membranes at full-term and near full-term. Methods: From January 2012 to January 2015 in the first people's hospital of Taizhou, a total of 450 pregnant women with premature rupture of membranes were recruited, whose gestational age were all over 35 weeks. According to wills of the women and their families, these included women were divided into observation group (n = 340) and control group (n = 110). The observation group included women with cervical mature (n = 225) and women with cervical immature (n = 115), and all of them had been induced immediately. Women in control group had been induced after waiting for 8-12hours. The outcomes included state of Labor , labor time, rate of amniotic fluid dyeing dung, delivery way, postpartum hemorrhage, and morbidity of mother and baby in perinatal, and analysis the rate over stimulate uterine and other adverse effects after using Dinoprostone. Results: In observation group, there was no statistical significance differences for postpartum hemorrhage, intrauterine infection, puerperal disease and neonatal morbidity of patients with cervical mature compared with that of cervical immature group(χ2 = 0.001, 2.943, 1.951, 2.943, P> 0.05).The incidence of postpartum hemorrhage in the observation group and the control group was no significant difference (χ2= 0.393, P > 0.05). The incidence rates of intrauterine infection, puerperal disease and neonatal morbidity of observation group were significant lower than those of control group (χ2 = 10.621, 17.413 and 14.130, P < 0.05). Rate of amniotic fluid turbidity of cervical immature group was higher than that of cervix mature group (χ2= 39.393, P < 0.05). The time of total labor of observation group was significantly shorter than that of control group (t = 3.0782, P < 0.01). Rate of vaginal delivery of observation group was higher than that of control group (χ2= 6.973, P > 0.05). There was no any serious adverse incident in both groups. Conclusions: Deciding induced labor way according to cervical maturity make obvious advantage for decreasing morbidity of perinatal mother and baby, and can short labor time.
2015 Vol. 23 (11): 759- [Abstract]（
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CHEN Hong
Objective: To explore the clinical efficacy of traditional Chinese medicine (TCM) combined with western medicine to treat tubal pregnancy. Methods: 412 patients with tubal pregnancy were divided into two group randomly: 203 patients in observation group were treated by TCM combined with western medicine, while 209 patients in control group were treated by laparoscopic fallopian tubes conservative surgery. The outcomes including time of serum β-hCG decreased to normal level, cure rate, Rate of fallopian tubes recanalization, intrauterine pregnancy rate, repeated ectopic pregnancy rate and living quality were compared between the two groups. Results: In the observation group, the time of serum β-hCG decreased to normal level and hospitalization days were longer than those of the control group (P<0.01), while hospitalization expenses were lower than that of the control group (P<0.05). There were no significant difference between the two groups in cure rate, rate of fallopian tubes recanalization and rate of intrauterine pregnancy (P>0.05). The rate of repeated ectopic pregnancy of observation group (12.09%) was lower than that of the control group (19.80%). After treatment, the living quality of women in both groups were improved, but the living quality of women in observation group were higher than those of the control group (P<0.01). Conclusion: Compared with laparoscopic fallopian tubes conservative surgery for women with tubal pregnancy, efficacy of treatment using TCM combined with western medicine is equivalent, but cost is less. In additional, the rate of repeated ectopic pregnancy is lower and living quality is higher. Therefore, treatment using TCM combined with western medicine is worthy popularized widely in clinical.
2015 Vol. 23 (11): 762- [Abstract]（
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