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ZHANG Wen, WU Shangchun
Objective: To evaluate the acceptability of manual vacuum aspiration (MVA). Methods: We searched CBMdisc (1978-2014), CNKI (1979-2014), Wanfang Database (1982-2014), VIP Database (1989-2014), PubMed (1966-2014), Cochrane Library and searched other related journals manually to screen randomized controlled trials (RCTs) of comparing MVA with electric vacuum aspiration (EVA). The quality of included trials was assessed. RevMan5.0 software was used for meta-analysis. Results: Five trials were included, in which 3 RCTs were graded B and 2 were graded C. There were no significant difference in the degree of patients' satisfaction with the operation between MVA group and EVA group ［RR (95%CI) value was 1.02 (0.87, 1.20)］. There were no significant difference in the proportion of patient who would choose the same type of procedure again between MVA group and EVA group ［RR (95%CI) value was 1.04 (0.91, 1.18)］. More providers in MVA group considered the procedure was difficult to conduct, showing statistically significant difference between the two groups ［RR (95%CI) value was 4.63 (2.14，9.99)］. Conclusion: Based on the current evidence, MVA has the similar acceptability compared to EVA. However, more providers consider MVA is difficult to conduct.
2015 Vol. 23 (7): 436- [Abstract]（
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ZHANG Ying, WANG Shangming, ZHANG Bin, et al
Objective: To explore the effects of chronic unpredictable mild stress (UCMS) on reproductive system in male rats. Methods: SPF SD rats were randomly divided into normal group and UCMS group. Rats in the UCMS group were given 28 days of chronic unpredictable mild stress, while those in the control group was normal fed. Body weight as well as the weight of testis and epididymis was measured. The number of sperm, sperm survival rate and sperm activity were evaluated. HE staining was utilized for observing the structure of rat testis. Results: Compared with the control group, the weight of testis and epididymis and the body weight of rats in UCMS group were remarkably decreased. The sperm activity decreased significantly, the rate of grade a and c sperm decreased significantly in UCMS group. The structure of testis in UCMS group was damaged compared with the control group. Conclusion: The chronic unpredictable mild stress can be harmful to the reproductive function of male rats.
2015 Vol. 23 (7): 440- [Abstract]（
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SHEN Yun, XU Jianfeng, CHEN Juan, et al
Objective: To explore the immature testis allotransplantation model in the mouse using the same strain ICR mouse as a recipient, and to make a improvement based on the previous reports. Methods: The donor was the immature testis of six-day ICR-mouse. The recipient was the same strain ICR mouse. The immature testis of ICR mice were transplanted into the back of the neck in the recipient mice. After 3, 4, 5 weeks, the status and the volume of the allograft were observed, and then the histopathology of the allograft was assessed. The level of TESK1 mRNA expression was analyzed by Q-PCR. Results: The volume of the allograft increased after allotransplantation. The average volume was (17.3±2.6) mm3 before transplantation, (203.1±14.3) mm3 after 3 weeks of transplantation, (236.4± 27.5) mm3 after 4 weeks of transplantation, (220.9±17.4) mm3 after 4 weeks of transplantation. Histopathologic results showed that seminiferous tubules developed well and the spermatogenic function recovered after immature testis allotransplantation. No significant differences of seminiferous tubules intact conditions were found among three groups after allotransplantation (P>0.05). The expression level of TESK1 mRNA increased after transplantation. The relative expression of TESK1 mRNA was (1.19±0.1) times before transplantation, (6.74±0.8) times in 3-week allograft, and (11.23±1.2) times in 5-week allograft the number of the control group (P<0.05). Conclusion: It is feasible that ICR mouse immature testis were allotransplanted using the same strain ICR mouse as a recipient.
2015 Vol. 23 (7): 443- [Abstract]（
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ZHANG Ning, TANG Xiaofeng, CHEN Ying, et al
Objective: To explore the influence of lead exposure on menstrual disorders, spontaneous abortion, high-quality embryo in women in women subjected to assisted reproductive technology. Methods: Women who were subjected to assisted reproductive technology for female infertility were recruited. The blood lead concentration was measured by graphite oven atomic spectrophotometer. Results: The average lead concentration was 30.98 (0-319.74) μg/L. The blood lead concentration exceeded the normal range in 21 (4.49%) women. No statistical relationships between the blood lead concentration with the incidence of menstrual disorders and spontaneous abortion as well as the good quality embryo rate were found. Conclusion: This study suggests that high concentration of blood lead may have no relationship with the incidence of menstrual disorders and spontaneous abortion as well as the good quality embryo rate. Large scale study is need to verify whether the lead pollution could result in the damage on female reproduction function and their offspring.
2015 Vol. 23 (7): 447- [Abstract]（
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LIN Min, CHE Min, HUANG Yilan, et al
Objective: To explore the genetic polymorphism of 11 Y-chromosome short tandem repeats (STR) loci in Fujian She ethnic population. Methods: Investigator Argus Y-12 reagent kit was used to conduct the co-amplification of gene and a genetic analyzer was used for genescan and analysis of the genotype from 103 unrelated individuals. Results: The frequencies range of 82 STR loci detected were 0.0097-0.6990. The gene diversity values (GD) was 0.4533-0.9596. Ninety-one haplotypes were found in 11 Y-STR loci, of which 81 were unique, 8 were found in 2 individuals, 2 in 3 individuals, and the haplotypes diversity values (HD) was 0.9728. Conclusion: The genetic distribution of the 11 Y-STR loci in Fujian She ethnic population groups shows favorable polymorphisms, which would be very powerful for population genetics and forensic practice.
2015 Vol. 23 (7): 451- [Abstract]（
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JIANG Chenglong, ZHANG Changjun
Objective: To explore the pregnancy outcome of frozen-thawed embryo transfer cycle with 3.75mg of GnRHa followed by hormone replacement in patients with polycystic ovary syndrome (PCOS). Methods: A total of 190 patients with PCOS seeking for frozen-thawed embryo transfer were divided into two groups. Women in group A were given hormone replacement (n=98) and those in group B used 3.75mg of GnRHa combined with hormone replacement (n=92) according to the endometrial preparation. The differences in implantation rate, pregnancy rate, miscarriage rate and reproductive hormone levels between the two groups were evaluated. Results: Compared with group A, women in group B achieved significantly higher pregnancy rate (70.6% vs. 51.0%, P<0.05), higher implantation rate (51.9% vs. 35.8%, P<0.05), and significantly lower luteinizing hormone level during the treatment. No significant differences were found between group A and group B in early abortion rate，ectopic pregnancy rate, multiple fetal rate and live birth rate（P all >0.05）. Conclusion: The hormone replacement after 3.75mg of GnRHa could improve PCOS frozen embryo transfer implantation rate and pregnancy rate.
2015 Vol. 23 (7): 455- [Abstract]（
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LI Hui, ZHOU Ping, HONG Shuzhen, et al
Objective: To explore the clinical effect and safety of cervical balloon on induction of cervical maturation in full-term gestational women with previous cesareans. Methods: Forty-five full-term gestational women with scar uterus were recruited as the experimental group and 45 full-term pregnancy women without scar uterus as the control group. Women in both groups used cervical ripening balloon for preinduction of cervical ripening and labor induction. The degree of cervical ripening, vaginal delivery rate, and stages of labor, delivery outcome and adverse reactions between two groups were compared respectively. Results: There were no significant difference in the efficiency of inducing cervical maturation between the two groups (80% vs. 85%, P >0.05). The vaginal delivery rate in the experimental group was lower than that of the control group (62% vs. 82%, P<0.05). Adverse reaction was found in two cases of the experimental group, and there was no significant difference between two groups (P<0.05). There were no significant differences in stages of labor and pregnancy outcome between two groups (P <0.05). Conclusion: The effect of cervical ripening balloon on induction of cervical maturation in full-term gestational women with or without previous cesareans is valuable and worth clinical application.
2015 Vol. 23 (7): 458- [Abstract]（
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QIAN Jinfeng, WANG Caiyan, ZHUGE Ting, et al
Objective: To explore the efficacy and safety of mifepristone combined with misoprostol for termination of pregnancy between 16 and 24 weeks of gestation. Methods: Women recruited were randomized to two groups: 53 in medical abortion group and 53 in ethacridine group. Routine surgical evacuation was only performed in ethacridine group after the expulsion of placenta. Results: The incidence of fetus expulsion was 94.3% in the medical group and 98.1% in the ethacridine group, showing no significant difference; The mean induction-to-abortion interval was (48.7±7.0) h and (38.5±9.4) h, showing significant difference in two groups; The uterine contraction-to-abortion time was (10.6±6.7) h and (14.2±9.0) h in two groups, showing significant difference；The incidence of surgical evacuation in medical group was 18.9% most of which was immediate evacuation. Conclusion: vaginal misoprostol combined with mifepristone without invasive procedures is effective and safe for termination of pregnancy between 16 and 24weeks of gestation.
2015 Vol. 23 (7): 461- [Abstract]（
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JIA Yuefeng, WANG Jing
Objective: To evaluate the effect of goal-direct therapy (GDT) on perioperative microcirculation in patients with ectopic pregnancy and hemorrhagic shock. Methods: Sixty adult patients suffering hemorrhagic shock with Ⅱ to Ⅲ of ASA score were randomly divided into two groups: the observation group (goal-direct therapy) and the control group (conventional infusion). Dynamic electrocardiogram (ECG), MAP, central venous pressure (CVP) and cardiac output (CO) were monitored. And heart rate (HR), CVP, MAP and serum lactate level, urinary volume were recorded at different times of 30 min before operation (T1), at 30 min (T2), 1 h (T3) and 1 h (T4) after beginning of the operation and the end of the operation (T5). Results: HR was highest while MAP and CVP were lowest at T1 in two groups (P<0.05). At T2 and T3, HR in the observation group was lower than that of the control group, while MAP and CVP in the observation group were higher than those of the control group (P<0.05). After the treatment, the serum lactate level at T3 and T4 were lower and the urinary volume at T3, T4 and T5 were higher in the observation group when compare with the control group (P<0.05). Conclusion: The stable hemodynamics and balanced microcirculation can be maintained by GDT in patients suffering hemorrhagic shock due to ectopic pregnancy.
2015 Vol. 23 (7): 465- [Abstract]（
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FU Ruihong, Han Yan, Wang Hui
Objective: To explore the clinical application value of postpartum hemorrhage prediction score combined with carprost suppository in prevention of postpartum hemorrhage. Methods: From January 2013 to May 2014, 125 delivery women were recruited in our hospital. Sixty-five women were given postpartum hemorrhage evaluation with prediction score combine with carprost suppository (study group), and 60 women with no intervention were as the control. The incidence of postpartum hemorrhage, the amount of bleeding and the intensity of uterus contractions in different periods of two groups were compared. Results: Compared with the control group, lower postpartum hemorrhage rate was found in the study group (16.92%), the amount of bleeding during delivery, 2 h and 24 h after delivery were less, the intensity of uterus contractions 10 min, 30 min and 60 min after delivery were higher (P all＜0.05). Moreover, compared with the high-risk group, there were lower incidence of postpartum hemorrhage in low-risk (3.84%) and mid-risk (9.52%) groups, the amount of bleeding during delivery, 2 h and 24 h after delivery were less, the intensity of uterus contractions 10 min, 30 min and 60 min after delivery were higher (P all＜0.05). Conclusion: Postpartum hemorrhage evaluation with prediction score combined with carprost suppository has higher clinical value for improving postpartum hemorrhage.
2015 Vol. 23 (7): 468- [Abstract]（
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PAN Qiangwei, CHEN Yumei, PAN Jiajia,et al
Objective: To investigate the clinical value of human papillomavirus (HPV) E6/E7 mRNA testing in patients with atypical squamous cell of undetermined significance (ASCUS). Methods: A total of 160 patients with ASCUS cytology had colposcopy/biopsy, HPVE6/E7 mRNA and high-risk (HR) HPV DNA testing. The testing results combined with pathological diagnosis were analyzed. Results: The positive rates of HPV E6/E7 mRNA for cervical intraepithelial neoplasia (CIN) II or worse were significantly higher those of CIN I or normal (P<0.05), and the results were similar with those of HR-HPV DNA testing. The sensitivity of HPV E6/E7 mRNA for detecting CINII or worse (73.9%) was similar with that of HR-HPV DNA testing (P>0.05), while the specificity (69.2%) was significantly higher than that of the latter (61.9%, P<0.05). Conclusion: Among patients with ASCUS, HPVE6/E7 mRNA is an effective indicator for colposcopy referral.
2015 Vol. 23 (7): 471- [Abstract]（
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