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Abstract Objective: To investigate the clinical value of human papillomavirus (HPV) E6/E7 mRNA testing in patients with atypical squamous cell of undetermined significance (ASCUS). Methods: A total of 160 patients with ASCUS cytology had colposcopy/biopsy, HPVE6/E7 mRNA and high-risk (HR) HPV DNA testing. The testing results combined with pathological diagnosis were analyzed. Results: The positive rates of HPV E6/E7 mRNA for cervical intraepithelial neoplasia (CIN) II or worse were significantly higher those of CIN I or normal (P<0.05), and the results were similar with those of HR-HPV DNA testing. The sensitivity of HPV E6/E7 mRNA for detecting CINII or worse (73.9%) was similar with that of HR-HPV DNA testing (P>0.05), while the specificity (69.2%) was significantly higher than that of the latter (61.9%, P<0.05). Conclusion: Among patients with ASCUS, HPVE6/E7 mRNA is an effective indicator for colposcopy referral.
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