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ZHANG Wen, WANG Kun, WU Shangchun
Objective: To evaluate the contraceptive efficacy of medicated GyneFix intrauterine device (IUD) when compared with other common IUDs. Methods: We searched medical databases including CNKI (19792014), CBMdisc (19782014), Wanfang Database (19822014), VIP Database (19892014) by computer. And we screened randomized control trials and then performed the metaanalysis by using RevMan5.0 software. Results: Fifteen articles from 580 literature were recruited for metaanalysis according to the inclusion and exclusion criteria. The rate of pregnancy with IUD in situ of medicated GyneFix IUD was lower than that of Yuangong copper 220 IUD when followed up at 12th month ［odd ratio (OR)=0.19 (95% confidence intervals (CI 0.080.47)］. And the rate of pregnancy with IUD in situ of medicated GyneFix IUD was lower than that of copper T220C IUD when followed up at 6th,12th month ［OR=0.18 (95%CI 0.050.68), 0.13 (95%CI 0.050.37), respectively］. The expulsion rate of medicated GyneFix IUD was lower than that of Yuangong cooper 220 IUD when followed up at 12th, 24th month ［OR=0.24 (95%CI 0.100.59), 0.09 (95%CI 0.020.39), respectively］. And the expulsion rate of medicated GyneFix IUD was lower than those of copper T380A IUD ［OR=0.17 (95%CI 0.040.76)］ and copper T220C IUD ［OR=0.21 (95%CI 0.080.55)］ when followed up at 12th month. The removal rate for medical reason of medicated GyneFix IUD was lower than that of Yuangong copper 220 IUD when followed up at 6th,12th month ［OR=0.39 (95%CI 0.200.77), 0.21 (95%CI 0.120.36), respectively］. The removal rate for medical reason of medicated GyneFix IUD was lower than that of copper T380A IUD when followed up at 3th, 6th,12th month ［OR=0.21 (95%CI 0.070.65), 0.11 (95%CI 0.040.31), 0.09 (95%CI 0030.23), respectively］. And the removal rate for medical reason of medicated GyneFix IUD was lower than that of copper T220C IUD when followed up at 6th,12th month ［OR=0.22 (95%CI 0.070.66), 0.23 (95%CI 0.110.48), respectively］. Conclusion: Medicated GyneFix can prevent the pregnancy effectively and reduce the expulsion rate and the removal rate for medical reason. So it has the favorable contraceptive efficacy and is worth using widely.
2015 Vol. 23 (01): 4- [Abstract]（
74
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GAO Lili, SHEN Jie, ZHANG Yue, et al
Objective: To explore the status of contraceptive use among migrant women applying for repeat abortions in Beijing in order to provide the scientific information for health education to them. Methods: Eighteen hospitals in six districts were stratified random sampled. Women were surveyed with a questionnaire in the outpatient before they experienced induced abortion. Results: About 32.4% of the respondents were in high risk of induced abortion. About 59.9% of them applied for induced abortion due to contraceptive failure and 32.6% for use of traditional contraceptives. It was found that 38.4% of the women did not use contraceptive during the first sexual activities after their previous abortion while 70.9% of them thought she was not in the risk of pregnancy. Contraceptive use during the first sexual activities after induced abortion was related to the degree of satisfaction with the family planning services. It would be influencing factors of repeat abortion that women dissatisfied with the service and received no suggestion on contraceptive use. About 504% of the women encountered problems in contraceptive use. Conclusion: Various health education should be provided to migrant women due to higher risk for the unwanted pregnancy. More emphasis on informed choices of contraceptive methods should be promoted to decrease the unwanted pregnancy.
2015 Vol. 23 (01): 12- [Abstract]（
83
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HUANG Qiaohong, LU Yanqiang, MA Shaojie, et al
Objective: To explore the polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, al298C and methionine synthase (MTRR) A66G gene among Chinese Han women in Jingang Town of Zhangjiagang City. Methods: A total of 348 women of childbearing age in Jingang Town of Zhangjiagang City were recruited into this study. Genomic DNA was extracted from oral mucosa cells. Taqman MGB technology was used to detect MTHFR and MTRR gene polymorphisms. The frequencies of different polymorphisms of MTHFR and MTRR were analyzed with HaploView 4.2 and SPSS 19.0. We also compared the differences of gene polymorphisms between the women in Jingang Town and other districts. Results: Among the Han women of reproductive age in Jingang Town, the frequency of MTHFR 677TT genotype(16.7%) was lower than those in Yantai (32.2%), Zhenjiang (21.8%, P all <0.05), while higher than those in Songzi (15.4%), Deyang (13.8%), Kunming (14.1%), Huizhou (10.9%, P all<0.05); The frequency of MTHFR 1298CC genotype(2.9%) was higher than those in Yantai (1.8%), Songzi (2.6%), Kunming (2.7%) and lower than those in Zhenjiang (3.5%), Deyang (6.3%), Huizhou (7.2%, P all <0.05); The frequency of MTRR 66GG genotype(3.5%) was significantly lower than those in Yantai (7.2%), Songzi(6.4%), Deyang (82%, P all<0.01). Conclusion: The MTHFR, MTRR polymorphism distribution of the Han women in Jingang Town is generally higher than those in the south with regional specificity. More and longer folic acid supplement should be improved so as to achieve the purpose of primary prevention.
2015 Vol. 23 (01): 15- [Abstract]（
61
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LUO Jie, LIU Jinhui, ZHOU Huimin, et al
Objective: To explore the status of the infection of Toxoplasma gondi (TOX), rubella virus (RV) and cytomegalovirus (CMV) among women of childbearing age in Nanchang to prevent the birth defect caused by the infection mentioned above. Methods: The clinical data, the positive rate and influential factors of TOX, RV and CMV infection from 15 879 women who once got preconception detection of antibody against TOX, RV and CMV in Reproductive Health Care Center of Jiangxi, Education Service Center of Nanchang Population Family Planning Commission and other sites were retrospectively analyzed. Results: Among women of childbearing age in Nanchang, the positive rate of TOX-IgM was 4.20%, the positive rate of TOX-IgG was 5.50%, the positive rate of RV-IgG was 96.70%, the positive rate of of CMV-IgM was 6.50%, and the positive rate of CMV-IgG was 95.20%. The residence place, season, history of animal contact and abnormal history of pregnancy were the important factors to influence the infection rate of three pathogens (Pall <0.05). Conclusion: According to infection characteristics of the three pathogenic microorganism, rural women should be listed as the main screening population, and the women with adverse pregnancy history should be coupled with more eugenics guidance. Furthermore, more public education for all women should be promoted. The pregnant women should take more care during the first trimester in order to reduce birth defects.
2015 Vol. 23 (01): 18- [Abstract]（
56
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ZHENG Ruihua, WANG Qiling, TANG Lixin, et al
Objective: To explore the knowledge and service utilization of preconception care among migrant women in order to provide technological supports to build a right and effective intervention model. Methods: A total of 779 women (378 migrant, 401 resident as control) who experienced preconception health examination were recruited from March to August, 2013. A questionnaire survey were conducted. Results: The average age of the respondents was 2519±3.34 years old. There was no significant difference in age, educational level or occupation between the migrant group and the control group (P all>0.05). The respondents knew little about preconception eugenic measures and services. Compared with the migrant group, women in the control group knew more about free access to these services and the importance of screening Mediterranean anemia through preconception eugenic check (P all<0.05). The migrant group got lower score for knowledge of birth defects than the control group. Conclusion: The scientific propaganda about knowledge and preconception care in the primary prevention of birth defect should be promoted in the inflow region of migrant population in order to improve the effect of primary intervention for birth defects among the target population.
2015 Vol. 23 (01): 21- [Abstract]（
59
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QIN Wensong, LIU Ying, QIN Huiling, et al
Objective: To explore the relationship between sperm DNA fragmentation and the outcome of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods: Sperm chromatin dispersion (SCD) was performed to determine DNA fragmentation index (DFI) in 208 IVF and 72 ICSI cycles. According to the test results, we divided the samples into low DFI group (<25%) and high DFI group (≥25%). The relationship between sperm DNA fragmentation and the fertilization rate, cleavage rate, good quality embryo rate, utilization rate of embryo and clinical pregnancy rate of two groups were compared. Results: No matter which fertilization method we chose, the fertilization rate, cleavage rate, good quality embryo rate, utilization rate of embryo and clinical pregnancy had no significant differences between the low DFI group and the high DFI group. Conclusion: DNA fragmentation rate may not affect the studied indicators and pregnancy outcome of IVF/ICSI.
2015 Vol. 23 (01): 25- [Abstract]（
71
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SUN Meifang, MU Huaxin
Objective: To explore the clinical effect of electrical stimulation combined with muscle training of pelvic floor muscles on postpartum pelvic floor dysfunction (PFD). Methods: A total of 337 women who were diagnosed with postpartum PFD in physical examination 42 days after delivery were divided into treatment group (n=158) and control group (n=179) according to their informed choice. Women in the treatment group were treated with electrical stimulation and pelvic floor muscle training, while those in the control group only by pelvic floor muscles training. Pelvic floor muscle tension and the occurrence of stress urinary incontinence 12 weeks after treatment were compared. Results: There was a significant difference in pelvic floor muscle strength before and after treatment in the treatment group (P<0.05)．The pelvic floor muscle tension in the treatment group was superior to that of the control group after treatment (P<0.05). And the occurrence rate of stress urinary incontinence in the treatment group was less than that of the control group (P<0.05). Conclusion: Pelvic floor muscles electrical stimulation combined with pelvic floor muscle training could have significant therapeutic effects on postpartum PFD, resulting in the improvement of patients' life quality.
2015 Vol. 23 (01): 29- [Abstract]（
58
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YANG Juan
Objective: To explore the clinical effect of mifepristone and misoprostol combined with rivanol in mid-trimester induction of labor in order to find a safer and more effective method of induced labor. Methods: A total of 120 patients applying for induction of labor were assigned into observation group (n=60) and control group (n=60) according to their informed choices. Intra-amniotic injection of 100 mg rivanol was conducted in the control group as well as the observation group. Women in the observation group were received 150 mg of mifepristone orally prior to the injection, and were inserted 200 g of misoprostol in posterior vaginal fornix after 24 hours. Results: The average onset time of contraction, total stage of labor and amount of postpartum hemorrhage of the observation group were obviously less than those of the control group (P all＜0.05). Birth canal damage was found in two women in the observation group and three in the control group, showing no significant difference between the two groups (P>0.05). Conclusion: Mifepristone and misoprostol combined with rivanol could obviously shorten the duration of induced labor with no serious adverse reaction.
2015 Vol. 23 (01): 32- [Abstract]（
70
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TAO Xiaohai, LIU Ruihua, SUN Bingui, et al
Objective: To explore the recent impact of mild or moderate varicocele (VC) on epididymis after vasectomy. Methods: Sixty male volunteers experiencing vasoligation were divided into study group (n=31) with mild or moderate varicocele and the control group (n=29) without varicocele. The operation was performed in accordance with the conventional vasectomy. Ultrasonography was used to measure the thickness of epididymal head, body and tail before and 1, 2, 3, 6, 12 months after operation, and incidences of the epididymal cyst as well as the epididymis granuloma were evaluated. Results: Epididymal head, body, tail were significantly thicker 1, 2, 3, 6, 12 months after vasoligation in both groups (P all<0.01), while there was no statistically significant difference between the two groups (P>0.05). The incidence of postoperative epididymis cyst were 12.9% and 13.8% in two groups, showing no statistically significant difference (P>0.05). The epididymis granuloma was not found in the two groups. Conclusion: Mild or moderate varicocele does not aggravate epididymal stasis and could not bring about epididymal stasis in the early stage of vasectomy.
2015 Vol. 23 (01): 34- [Abstract]（
61
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WANG Haiyu
Objective: To investigate the clinical value of the two-dimensional ultrasound combined with four-dimensional ultrasound in the diagnosis of fetal malformation in different gestational weeks. Methods: The pregnant women with different pregnant weeks from January 2010 to November 2012 were enrolled to subject to two-dimensional ultrasound screening during early pregnancy, the second trimester and late pregnancy. Women initially suspected to have fetal malformation were underwent two-dimensional ultrasound and four-dimensional ultrasonography. The two-dimensional ultrasound examination results and the two-dimensional ultrasound examination combined with four-dimensional ultrasound results and clinical delivery results were compared and analyzed. Results: A total of 2930 fetus were labored from 2891 pregnant women, 124 congenital anomalies were detected through the clinical observation and follow-up, of which 35 genito urinary system, 31 digestive system, 23 heart, 14 pleural effusion, 8 fetal tumor, 8 skin edema, 5 limbs fracture malformation. The accuracy rate of two-dimensional ultrasound combined with four-dimensional ultrasound in the diagnosis of fetal malformation was significantly higher than that of simple two-dimensional ultrasound examination (P<0.05). Conclusion: The ultrasound for diagnosis is available for the severe fetal deformity in early pregnancy, and partly screening for fetal structural abnormalities during the second trimester, and it can increase the detection rate of late onset fetal malformation in the third trimester of pregnancy. The ultrasound examination is an important method for examination of fetal deformity, and combination of two-dimensional and four-dimensional ultrasonography can significantly improve the diagnostic rate of fetal malformation and is recognized as a preferred method for timely diagnosing the fetal abnormalities and reducing the birth defects. It is recommended that the diagnosis of fetal deformity should be based on the ultrasonic characteristics of different gestational weeks, resulting in improving the detection rate and providing reliable reference for clinical diagnosis.
2015 Vol. 23 (01): 38- [Abstract]（
48
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