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| Relationship between sperm DNA integrity and the outcome of in vitro fertilization/intracytoplasmic sperm injection |
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Abstract Objective: To explore the relationship between sperm DNA fragmentation and the outcome of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods: Sperm chromatin dispersion (SCD) was performed to determine DNA fragmentation index (DFI) in 208 IVF and 72 ICSI cycles. According to the test results, we divided the samples into low DFI group (<25%) and high DFI group (≥25%). The relationship between sperm DNA fragmentation and the fertilization rate, cleavage rate, good quality embryo rate, utilization rate of embryo and clinical pregnancy rate of two groups were compared. Results: No matter which fertilization method we chose, the fertilization rate, cleavage rate, good quality embryo rate, utilization rate of embryo and clinical pregnancy had no significant differences between the low DFI group and the high DFI group. Conclusion: DNA fragmentation rate may not affect the studied indicators and pregnancy outcome of IVF/ICSI.
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