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An Jinxia , Ni Yali, Liu Zhen
Objective: To evaluate the efficacy and safety of letrozole and clomiphene citrate for ovulation induction in infertile women. Methods: We searched paper databases such as PubMed (from 1966 to 2011), EMBASE (from 1966 to 2011), CBMdisc (from 1978 to 2011), CNKI (from 1994 to 2011) and VIP (from 1989 to 2011). Relevant randomized controlled trials (RCTs) were selected for quality assessment according to Cochrane Reviewer′s handbook 4.2.5 and meta-analysis with RevMan 4.2.10 software. Results: Fourteen RCTs involving in 1 379 women and 2342 cycles were included. All data were divided into polycystic ovary syndrome (PCOS) and normal ovulation subgroups. The results of meta-analysis showed that no significant differences were found in the cycle pregnancy rate (RR: 0.99, 95%CI: 0.75 to 1.30), pregnancy rate of each women (RR: 1.21, 95%CI: 0.92 to 1.58 ), ovulation rate (RR:1.04, 95%CI: 0.92 to 1.17 ), and miscarriage rate (RR: 0.55, 95%CI: 0.23 to 1.29). But serum estrodiol concentration on the day of human chorionic gonadotrophin (hCG) was significantly lower in the letrozole group in 2 RCTs of the PCOS subgroup and 4 RCTs of the normal ovulation subgroup (P＜0.05). The endometrium on the day of hCG administration was significantly thicker in the letrozole group in 3 RCTs of the PCOS subgroup and 2 RCTs of the normal ovulation subgroup(P＜0.05). Conclusion: Letrozole is at least as effective as clomiphene for inducing ovulation and achieving pregnancy in patients with infertility. Current research does not demonstrate that letrozole can replace clomiphene as a first-line medicine for ovulation induction in patients with infertility.
2012 Vol. 20 (2): 83- [Abstract]（
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Li Shuanming, Wang Jian, Yang Jing, Zhao Fuxi
Objective: To investigate the feasibility of quantitative detection of expression of maspin gene methylated (M-maspin) and unmethylated (U-maspin) in maternal plasma with methylation-specific PCR and TaqMan probe. Methods: Ninety pregnant women at the first (n=30), second (n=30) and third (n=30) trimester of pregnancy were recuited as study groups, and thirty normal non-pregnant women as the control group. Free DNA of plasma samples was extracted, then a standard curve using serial dilutions of the standard preparation was employed. The expressions of M-maspin and U-maspin gene were detected by methylight technology for maternal and fetal cell-free DNA, respectively. Results: The expression of U-maspin gene in maternal plasma of three pregnant women at the first trimester of pregnancy was not detected. The mean concentrations of U-maspin gene were 57 copies per milliliter in the first trimester, 121 copies per milliliter in the second trimester, and 561 copies per milliliter in the third trimester. Conclusion: U-maspin gene may be considered as an epigenetic marker to detect the fetal DNA in maternal plasma. It is easy and precise to detect the microamount of U-maspin gene in maternal plasma by methylight technology.
2012 Vol. 20 (2): 90- [Abstract]（
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Li Yuyan, Wu Junqing, Zhou Ying, Wang Ruiping, Zhan Shaokang, Yu Jinming, Cheng Jianping
Objective: To explore acquisition of the contraceptive knowledge at the current place of residence, so as to provide a basis for high quality services of family planning and reproductive health among migrants in Shanghai. Methods: A cluster and stratified sampling was used to recruited 2 001 migrants and they were interviewed by the trained investigators with a questionnaire. Results: The awareness of contraceptive methods was less than 70%, and fewer migrants knew side-effects of each contraceptive method. About 42.73% acquired contraceptive knowledge at the current place of residence last year. The average knowledge score of migrants who acquired knowledge at the current place of residence last year was 31.39±20.72, higher than that (24.06±20.54) of those without acquisition of the knowledge (P<0.01). The main knowledge sources were brochures (30.76%), movie, magazine and newspaper (16.96%), and blackboard (16.26%). More respondents younger and with higher educational level acquired contraceptive knowledge. And more unmarried respondents with sexual behaviour and more married ones acquired contraceptive knowledge than those who were not married and without sexual behaviour. In addition, more respondents working in a factory acquired contraceptive knowledge than those serving for a construction site and an entertainment site. Conclusion: Fewer migrants acquire contraceptive knowledge at the current place of residence. The age, marriage status, educational level and occupational place have impacts on acquisition of contraceptive knowledge. The IEC and counseling service of family planning and reproductive health should be improved for migrants, especially for those who are younger and have no sexual behaviour, and those with lower educational level and working in building sites and service/entertainment sites.
2012 Vol. 20 (2): 94- [Abstract]（
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Zhao Rui, Wu Junqing, Wang Ruiping, Zhou Ying, Li Yuyan1, Zhang Yufeng, Zhan Shaokang, Cheng Jianping
Objective: To analyze the service and awareness of emergency contraceptive pills in floating population and to explore the potential influential factors. Methods: An epidemiological cross-sectional survey was adopted in this study. The chi-square test and logistic regression analysis were used to analyze the independent variables and influential factors. Results: A total of 1 414 respondents experienced sexual behavior. There were 1 300 respondents (91.94%) who had the contraceptive use when having sexual intercourse. About 11.46% of those used emergency contraceptive pills. There were 27.16% who didn't know what kinds of emergency contraceptive pills they had used. The utilization rate of emergency contraceptive pills was lower among married respondents than those of unmarried ones (OR: 0.43, 95%CI: 0.25-0.73). Conclusion: There are some problems among floating population for emergency contraceptive pills use mainly because of poor knowledge. It is necessary to carry out IEC programme on emergency contraceptive pills for floating population to strengthen the standard use.
2012 Vol. 20 (2): 99- [Abstract]（
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Ma Xiaohong, Xu Xian
Objective: To explore the immune pathogenesis of premature ovarian failure (POF) by evaluating serum interleukin-1α (IL-1α ), interleukin-1α (IL-1α ) and lymphocyte subsets concentrations. Methods: Thirty women with POF were recruited as the study group, and 30 healthy women with regular menstrual cycle and normal ovulation served as the control group. The serum IL-1α, IL-1β, lymphocyte subsets concentrations were evaluated. Results: There was no significant difference in serum IL-1α concentration between the two groups (P＞0.05), and IL-1β level in the study group was significantly lower than that of the control group (P＜0.05). There were no significant differences in the concentrations of T+B+NK, CD3, CD4, CD8, CD4/CD8, CD19, CD16+56 between the two groups (P all＞0.05). Conclusion: The lower serum concentration of IL-1 could imply autoimmune disorders in POF patients.
2012 Vol. 20 (2): 103- [Abstract]（
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Deng Yun, Ding Hui
Objective: To explore the effect of Shengxuening Tablet on anemia in women during perinatal period. Methods: A retrospective, randomised, controlled and clinical research was conducted. A total of 260 women with anemia during perinatal period were divided into two groups, and 130 women for each group. Women in the treatment group were given 0.5g of Shengxuening Tablet orally, twice a day for the mild anemia and three times each day for the moderate and severe anemia. Women in the control group were only guided for nutrition. Results: Before the treatment, there were no significant differences in age, body weight, erythrocyte count, levels of hemoglobin, serum ferritin (SF) and transferrin saturation between the two groups. After the treatment, levels of hemoglobin, SF and total iron binding capacity in the treatment group were 108.6±12.6g/L, 12.26±4.38 mol/L and 63.22±9.78 mol/L, respectively, and the erythrocyte count was 4.18±0.56×1012/L. The effective rates were 87.7% in the treatment group and 71.6% in the control group. Conclusion: Shengxuening Tablet is effective for the treatment of anemia in women during perinatal period.
2012 Vol. 20 (2): 106- [Abstract]（
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Wang Fengyu, Ma Linxian, Li Congmin, Chang Mingxiu, Feng Huigen, Zhang Jinzhi, Meng Li, Wang Yuwei, Liu Zhiyou
Objective: To detect the incidence of 22q11 microdeletion in the children with different kinds of congenital heart disease (CHD) and to explore the feasibility of multiplex ligation-dependent probe amplification (MLPA) for detection of 22q11 microdeletion in CHD. Methods: We detected 22q11 micro-deletions in 120 CHD children with MLPA. Results: 22q11 microdeletions were found in 10 children (8.33%). Among them, there were three children with ventricular septal defect (VSD), five with tetralogy of fallot (TOF), one with pulmonary artery stenosis (PAS) and one with double outlet right ventricle (DORV). In addition, 22q11 duplication was detected in one child with PAS (0.83%). Conclusion: There are a proportion of 22q11 microdeletion in CHD children. MLPA is a rapid, convenience and effective method for detection of 22q11.2 microdeletion.
2012 Vol. 20 (2): 109- [Abstract]（
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Zhao Jun, Wang Aiming, He Xiaoling
2012 Vol. 20 (2): 132- [Abstract]（
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Guo Cuicui, Li Honggang, Xiong Chengliang
2012 Vol. 20 (2): 134- [Abstract]（
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Wu Junqing
2012 Vol. 20 (2): 142- [Abstract]（
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