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| Correlation between the clinical grade of cervical squamous intraepithelial lesions of patients with human papillomavirus infection (HPV) and their typing of HPV infected |
| 1.Haiyan County People’s Hospital, Jiaxing, Zhejiang Province, 314300；2.Shaoxing Women and Children’s Health Care Hospital, Shaoxing, Zhejiang Province |
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Abstract To explore the correlation between the clinical grade of cervical squamous intraepithelial lesions (SIL) of patients with human papillomavirus (HPV) infection and their typing of HPV infected. Methods: The clinical data of 300 patients with SIL by HPV-infected who had treated in hospital from April 2021 to April 2023 were included in this study, including 100 cases with the high-grade SIL (HSIL) in group A and 200 cases with the low-grade SIL (LSIL) in group B. The general data and the genotype of HPV-infected of the patients were compared between the two groups. Multivariate logistic regression analysis was performed to analyze the risk factors affecting the clinical grade of SIL of the patients with HPV infection. The distribution of HPV genotypes of the patients in the two groups was analyzed. Results: The proportions of the age >40 years old and the number of sexual partners ≥2 people, and the infection rate of the high-risk HPV of the patients in group A were significantly higher than those of the patients in group B (P<0.05). The top two HPV infection rates of the patients in group A were HPV35 (20.0%) and HPV52 (17.0%), and the top two HPV infection rates of the patients in group B were HPV39 (19.5%) and HPV33 (12.5%). The age >40 years old, the number of sexual partners ≥2 people and the high-risk HPV infection of the patients were the independent risk factors of their clinical grade of SIL (P<0.05). Conclusion: The advanced age, the more number of sexual partners and the high-risk HPV infection of the patients are all the influencing factors of their clinical grade of SIL, and the infection rates of HPV35, HPV52, HPV39, HPV33 and other subtypes of HPV of the patients with SIL are high, so which should be paid high attention in clinic.
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