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| Situation of the neonatal intrauterine infection of pregnant women with hepatitis B virus infection and its correlation with the viral load |
| 1.Jiashan County Maternal and Child Health Care Hospital, Jiashan, Zhejiang Province, 314100；2.Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang Province |
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Abstract To explore the situations of the neonatal intrauterine infection of pregnant women with different types of hepatitis B virus (HBV) infection and with different HBV-DNA load, and to study the correlation between the women with different types of HBV infections and their cytokine levels. Methods: A total of 100 pregnant women with HBV surface antigen (HBsAg) positive and their newborns who delivered at term after prenatal examination in hospital from January 2020 to October 2023 were selected in this study. The incidence of the neonatal intrauterine infection was calculated. The HBV viral load of the women was detected. The incidence of the neonatal intrauterine infection was compared among the women with different types of HBV infection and among the women with different HBV-DNA load. The differences of the interleukin-6 (IL-6) and interferon γ (IFN-γ) levels were compared among the women with different HBV-DNA load. Spearman correlation coefficient was used to analyze the correlation between the HBV load of the pregnant women and their IL-6 and IFN-γlevels. Results: Among 100 pregnant women, there were 36 (36.0%) cases with the positive HBsAg, HBeAg and HBcAb (in group A) and 64 (64.0%) cases with the positive HBsAg, HBeAb and HBcAb (in group B). The incidence of the neonatal intrauterine infection (22.2%) of the women in group A was significantly higher than that (3.1%) of the women in group B (P<0.05). There were 6 women with the negative HBV, 62 women with 103-105 HBV load of and 32 women with ＞105 HBV load. The incidence of the neonatal intrauterine infection (4.8%) and the level of IL-6 (8.11±0.89 pg/ml) of the women with 103-105 HBV load were Significantly lower than those (21.9% and 11.26±1.56 pg/ml) of the women with ＞105 HBV load. The IL-6 level of the women was positively correlated with their HBV load. The level of IFN-γ (68.47±7.10 pg/L) of the women with 103-105 HBV load of was significantly higher than that (51.22±5.65 pg/L) of the women with ＞105 HBV load, and which of the women was negatively correlated with their HBV load (all P<0.05). Conclusion: The risk of the neonatal intrauterine infection of the pregnant women with HBV infection increases. The type of the HBV infection of the pregnant women is mainly the positive HBsAg, HBeAb and HBcAb. The risk of the neonatal intrauterine infection of the pregnant women with the positive HBsAg, HBeAg and HBcAb or the women with high HBV load increases is high. The high HBV load of the pregnant women will increase their neonatal intrauterine infection rate, and which may be related to the regulation of Th1/Th2 immune imbalance of the women.
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