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| Efficacy of the dual energy CT combined with the levels of serum proteininduced by vitamin K absence or antagonist-II and N-myc downstream regulated gene 4 for diagnosing of ovarian cancer |
| The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, 510145 |
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Abstract To explore the application value of dual energy CT combined with serum protein-induced by vitamin K absence or antagonist-II (PIVKA-Ⅱ) and N-myc downstream regulated gene 4 (NDRG4) detections of women for diagnosing their ovarian cancer. Methods: From February 2020 to May 2023, 105 women with ovarian cancer who had received treatment were included in group A, and 100 women with benign ovarian tumors who had received treatment were included in group B, and in addition, 90 women who had accepted healthy examinees were included in group C. The women in the three groups had undergone dual energy CT examination, and values of the normalized iodine concentration (NIC) and energy spectrum curve slope (k) of the dual energy CT parameters of the women in the three groups were measured. The serum PIVKA-Ⅱ and NDRG4 levels of the women in the three groups were detected. Receiver operator characteristic (ROC) curve was applied to analyze the diagnostic value of the dual energy CT parameters combined with the serum PIVKA-II and NDRG4 levels of the women for diagnosing their ovarian cancer. Pearson method was applied to analyze the correlation between the serum PIVKA-Ⅱ and NDRG4 levels of the women and their dual energy CT parameters. Results: The NIC and k values, and the serum PIVKA-Ⅱ level of the women in group C, in group B and in group A had increased gradually, while the NDRG4 level of the women in group C, in group B and in group A had decreased gradually. The area under the curve (AUC) of the NIC value, the k value, the serum PIVKA-Ⅱ level and the NDRG4 level of the women for diagnosing their ovarian cancer were 0.785, 0.696, 0.832 and 0.799, respectively. The AUC of the combined the NIC and k values and levels of the serum PIVKA-Ⅱ and NDRG4 of the women for diagnosing their ovarian cancer was 0.937, and which was the highest (all P＜0.05). The serum PIVKA-Ⅱ level of the women with ovarian cancer was positively related to their NIC and k values, and the NDRG4 serum level of the women with ovarian cancer was negatively related to their NIC and k values. The parameters of the dual energy CT, and the serum PIVKA Ⅱ and NDRG4 levels of the women with ovarian cancer were related to the FIGO staging, lymph node metastasis and differentiation degree of their ovarian cancer (P＜0.05). Conclusion: The parameters of the dual energy CT, and the serum PIVKA Ⅱ and NDRG4 levels of the women have certain diagnostic values for their ovarian cancer. The diagnosis value of the combined of the dual energy CT parameters, and the serum PIVKA Ⅱ and NDRG4 levels of the women for their ovarian cancer is the highest.
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