|
|
|
| Transvaginal ultrasound combined with carcinoembryonic antigen carbohydrate antigen 125 and 153 for differential diagnosing the benign or malignant uterine space-occupying lesions |
| The First Affiliated Hospital of Anhui University of Technology, Huainan, Anhui Province, 232000 |
|
|
|
|
Abstract To investigate the value of the transvaginal ultrasound combined with the levels of carcinoembryonic antigen(CEA), carbohydrate antigen(CA) 125 and 153 of patients for differential diagnosing their benign or malignant uterine space-occupying lesions. Methods: The clinical data of 117 patients with suspected uterine space-occupying lesions from February 2021 to May 2023 were collected. These patients were divided into 56 patients with malignant uterine space-occupying lesions(endometrial cancer) in group A and 61 patients with benign uterine space-occupying lesions(endometrial benign polyps) in group B according to the results of their uterine dilatation and curettage or postoperative pathological examination. The differences of the results of the transvaginal ultrasound examination and the serum indexes levels of the patients were compared between the two groups. Receiver operating characteristic(ROC) curve was used to analyze the efficacy of the result of the transvaginal ultrasound examination and the serum indexes levels of the patients for differential diagnosing their benign or malignant uterine space-occupying lesions. Results: There was no significant difference in the peak systolic blood flow velocity of the patients between the two groups(P>0.05). The resistance index of the patients in group A was significantly lower than that of the patients in group B. The endometrial thickness of the patients in group A was significantly higher than that of the patients in group B. The levels of serum CEA, CA 125 and CA 153 of the patients in group A were significantly higher than those of the patients in group B(all P<0.05). The results of ROC curve showed that the AUC of the transvaginal ultrasound examination, the serum the CEA level, the CA 125 level, the CA 153 level, or the combination of the transvaginal ultrasound examination and the levels of the CEA, CA125 and CA153 of the patients for differential diagnosing their benign or malignant uterine space occupying lesions were 0.822, 0.713, 0.728, 0.797 and 0.915, respectively, and all of which had diagnostic values, but the combination of the transvaginal ultrasound examination and the levels of the CEA, CA125 and CA153 of the patients for differential diagnosing their benign or malignant uterine space occupying lesions had the highest value. Conclusion: The combinations of the transvaginal ultrasound examination and the levels of the CEA, CA125 and CA153 of the patients for differential diagnosing their benign or malignant uterine space occupying lesions have the higher efficacy and better clinical application value.
|
|
|
|
|
|
|
|
|
