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| Correlation between the expression levels of phosphatidylinositol 3-kinase and phosphorylated protein kinase B in serum and in placental tissues of pregnant women with gestational diabetes mellitus and their insulin resistance |
| Sanmen County People’s Hospital, Taizhou, Zhejiang Province, 317100 |
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Abstract To explore the correlation between the expression levels of phosphatidylinositol 3-kinase (PI3K) and phosphorylated protein kinase B (P-AKT) in serum and in placental tissues of pregnant women with gestational diabetes mellitus (GDM) and their insulin resistance. Methods: 147 pregnant women with GDM were selected in study group and 71 healthy pregnant women were selected in control group from January 2022 to December 2022. The expression levels of PI3K and P-AKT in serum and in placental tissues and the related indexes of blood glucose and insulin resistance of the women in the two groups were detected. The correlation between the expression levels of PI3K and P-AKT in serum and in placental tissues of the women and their homeostasis model assessment of insulin resistance (HOMA-IR) value was analyzed, and their predictive efficacy for the occurrence of insulin resistance of the women was also analyzed. Results: The levels of PI3K (0.81±0.17pg/L) and P-AKT (0.64±0.15pg/L) in serum of the women in study group were significantly higher than those (0.34±0.06pg/L and 0.30±0.07pg/L) of the women in the control group. The mRNA expressions of PI3K (1.09±0.23) and P-AKT (1.52±0.32) in placental tissue of the women in study group were significantly higher than those (0.54±0.10 and 0.67±0.13) of the women in the control group. The expressions of PI3K and P-AKT of the women were positively correlated with their HOMA-IR value (all P<0.05). The abnormal increased expressions of PI3K and P-AKT of the women with GDM in serum and in placenta tissue were the risk factor of their insulin resistance (P<0.05). Conclusion: The levels of PI3K and P-AKT of the women with GDM in serum and in placental tissues are increased abnormally, and which are the risk factors of the insulin resistance of these women.
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