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| Correlation between the levels of serum serum homocysteine, folic acid, and methylenetetrahydrofolate reductase of pregnant women and their pregnancyinduced hypertension occurrence |
| Chengdu Pidu District Maternal and Child Health and Family Planning Service Center (Chengdu Pidu District Maternal and Child Health Care Hospital), Chengdu, Sichuan Province, 611730 |
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Abstract To explore the correlation between the levels of serum homocysteine (Hcy), folic acid (FA), and methylenetetrahydrofolate reductase (MTHFR) of pregnant women and their pregnancy-induced hypertension (PIH) occurrence. Methods: 104 pregnant women with PIH were included in study group, and 67 healthy pregnant women were included in control group from October 2020 to October 2022. The women in the study group were divided in group A (women with mild PIH), group B (women with moderate PIH), and group C (women with severe PIH). The genotypes and alleles of MTHFR of the women were determined by fluorescence quantitative PCR. The serum Hcy and FA levels and the polymorphism of MTHFR gene C677T of the women were compared among these groups. Spearman correlation analysis was used to analyze the correlation between the serum Hcy and FA levels of the women and their severity of PIH. Logistic regression analysis was used to evaluate the risk factors of PIH of the women. Results: The levels of CRP, UA, TC, TG, ApoA1, ApoB, and Hcy of the women in the study group were significantly higher than those of the women in the control group, but the FA level of the women in the study group was significantly lower than that of the women in the control group. The CT and TT genotype and the total mutated T allele frequency of the MTHFR gene 677 of the women in the study group were significantly higher than those of the women in the control group, and all which of the women had significant differences among group A, group B, and group C (all P<0.05). Spearman correlation analysis showed that the serum Hcy level of the women in the study group was positively correlated with their severity of PIH, but the FA level was negatively correlated with their severity of PIH (P<0.05). Multivariate logistic regression analysis showed that genotype CT, genotype TT, and T alleles of the MTHFR gene 677 of the women were all the independent risk factors of their PIH occurrence (P<0.05). Conclusion: The level of serum Hcy of the pregnant women with PIH increases abnormally, the level of FA decreases significantly, and both of which are related to the severity of PIH. Early detection of the levels of the serum Hcy and FA of the women can provide evidences for evaluating their severity of PIH. The genotype CT, genotype TT, and T alleles of the MTHFR gene 677 of the women are all their independent risk factors of PIH occurrence.
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