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| Correlation between the semen quality and sperm movement of patients with prostatitis and their macrophage colony-stimulating factor and nuclear transcription factor -kB levels in prostatic fluid |
| Sichuan Friendship Hospital, Chengdu, Sichuan Province, 610066 |
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Abstract To study the correlation between the semen quality and sperm motion parameter of patients with prostatitis and their levels of macrophage colony-stimulating factor (M-CSF) and nuclear transcription factor-kB (NF-kB) in prostatitis patients. Methods: 300 patients with prostatitis diagnosed and treated in hospital from May 2019 to December 2022 were selected in study and divided into group A (patients with mild prostatitis), group B (patients with moderate prostatitis), group C (patients with severe prostatitis). 95 healthy men who came to hospital for physical examination during the same period were selected in control group. The semen quality, the values of sperm motion parameter, and the levels of M-CSF and NF-kB in prostatic fluid of the men in the study group and control group were detected. The correlation between the semen quality and values of sperm motion parameter of the patients and their levels of M-CSF and NF-kB in prostatic fluid was analyzed. Results: The semen volume, the pH value, the sperm concentration, the total sperm motility, the sperm survival rate, and the percentage of forward motile sperm of the patients in the study group were significantly lower than those of the men in the control group, while the semen liquefaction time, and the levels of M-CSF and NF-kB of the patients in the study group were significantly higher than those of the men in the control group (P<0.05). The semen volume, the semen liquefaction time, and the levels of M-CSF and NF-kB of the patients in group A, in group B, and in group C had increased gradually. The pH value, the sperm concentration, the total sperm motility, the sperm survival rate, and the percentage of forward motile sperm of the patients in group A, in group B, and in group C had decreased gradually. The semen volume and the sperm liquefaction time of the patients in the study group were positively correlated with their M-CSF and NF-kB levels, while the pH value, the sperm concentration, the sperm survival rate, the total sperm motility, and the percentage of forward motile sperm of the patients in the study group were negatively correlated with their M-CSF and NF-kB levels (all P<0.05). Conclusion: The semen quality parameters, the sperm movement parameters, and the NF-kB and MSCF levels of the patients with prostatitis are abnormally expressed, and the semen quality and sperm movement of the patients with prostatitis are closely correlated with their NF-kB and MSCF levels.
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