|
Abstract To analyze the correlation between the serum amyloid A1 (SAA1) and tumor necrosis factor alpha (TNF-α) levels of women with epidural labor analgesia and their fever during labor and delivery outcomes. Methods: The clinical data of 145 women who had received epidural labor analgesia from January 2021 to December 2021 were collected. According to whether fever or not, these women were divided into the group A (87 women without elevated body temperature) and group B (58 women with elevated body temperature). The analgesic effect evaluated by VAS score and Bromage grading, and the levels of serum SAA1 and TNF-α of the women were compared between the two groups. The women in group B were further divided in group B1 (47 women with normal delivery outcomes) and group B2 (11 women with adverse delivery outcomes) according to the delivery outcomes, and the levels of serum SAA1 and TNF-α of the women were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the predictive values of the serum SAA1 and TNF-α levels of the women for their elevated body temperature during epidural labor analgesia. Results: There were no significant differences in the scores of VAS and Bromage grade, and the serum SAA1 and TNF-α levels at 30 min before labor analgesia of the women between group A and group B (P＞0.05). The SAA1 level at 2h after labor analgesia delivery (7.81±0.75 mg/L) and at 24h after delivery (7.04±0.79 mg/L), and the TNF-α level at 2h after labor analgesia delivery (5.34±0.38 ng/ml) and at 24h after delivery (4.72±0.78 ng/ml) of the women in group B were significantly higher than those (5.62±0.93 and 3.54±0.59 mg/L, and 3.28±0.54 and 3.54±0.59 ng/ml) of the women in group A (P<0.05). The area under the curve of the serum SAA1 level and TNF-α level of the women with fever during epidural labor analgesia for predicting their adverse delivery outcomes were 0.732 and 0.812, the sensitivity of which were 81.8% and 90.9%, and the specificity of which were 63.8% and 72.3%. Conclusion: The serum SAA1 and TNF-αlevels of the women with epidural labor analgesia are closely related to the maternal fever during labor and their adverse delivery outcomes, and which can predict their delivery outcomes.
|
|
|
|
|
|
