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| Prediction values of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio during the first trimester of pregnancy combined with ultrasound umbilical artery resistance indexes during the second trimester of pregnancy of pregnant women for their early-onset preeclampsia |
| 1. Suzhou Science and Technology City Hospital, Suzhou, Jiangsu Province, 215000; 2. Suzhou Hospital Affiliated to Nanjing Medical University; 3.Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong Province |
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Abstract To observe the prediction values of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) during the first trimester of pregnancy combined with ultrasound umbilical artery resistance indexes (UA-RI) during the second trimester of pregnancy of pregnant women for their early-onset preeclampsia (EOPE). Methods: 2000 pregnant women who had been registered in hospital for prenatal examination from June 2019 to June 2022 were selected in this study. The blood samples were collected to detect the values of NLR and PLR during 10-13 gestational weeks of pregnancy, and the UA-RI value of the women was examined by ultrasound during 20-24 gestational weeks. These women were followed up to the end of pregnancy, and the occurrence of EOPE of the women was observed. The pregnant women with EOPE were included in study group, and the pregnant women without EOPE were selected in control group based on the ratio of 1:3. The clinical data, the values of NLR, PLR, and UA-RI of the women were compared between the two groups. The values of NLR, PLR, and UA-RI of the women with different severity of EOPE were observed. The correlation between the values of NLR, PLR, and UA-RI of the women and their severity of EOPE was analyzed. Logistic regression analysis was used to analyze the influencing factors of EOPE. Receiver operating characteristic (ROC) curve was drawn to explore the predictive efficacy of the values of NLR, PLR, and UA-RI of the women for their EOPE. Results: A total of 2000 pregnant women were followed up until delivery, and 357 women were lost to follow-up. Among the 1643 pregnant women who had completed the followed up, there were 64 (3.9%) women in the study group and 192 women were randomly selected from the other 1579 women without EOPE in the control group. The values of NLR and UARI of the women in the study group were significantly higher than those of the women in the control group, and the PLR value of the women in the study group was significantly lower. The UA-RI of the women with severe EOPE was significantly higher than that of the women with non-severe EOPE (all P<0.05). There were no significantly difference in the values of NLR and PLR between the women with severe EOPE and the women with non-severe EOPE (P＞0.05). Pearson correlation analysis showed that the UA-RI value of the women was positively correlated with their severity of EOPE (P<0.05). Logistic regression analysis showed that the age, and the abnormal increased NLR and UA-RI values of the women were the independent risk factors of their EOPE, and the increased PLR value of the women was the independent protective factor of their EOPE (all P<0.05). ROC curve showed that the area under the curve (AUC) of the NLR value, the PLR value, and the UA-RI value of the women for predicting their EOPE occurrence were 0.729, 0.599, and 0.892, respectively, which had certain predictive significance for EOPE, and the combined of the values of NLR, PLR, and UA-RI for EOPE had the highest prediction efficiency (AUC=0.920). Conclusion: The values of NLR and PLR of the pregnant women during the first trimester of pregnancy combined with the ultrasound umbilical artery resistance indexes UA-RI of the pregnant women during the second trimester of pregnancy are closely related to the occurrence of their EOPE. The combined of the values of NLR, PLR, and UA-RI of the women can improve the predictive efficiency of their EOPE.
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