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| Interaction between the serum 8-hydroxydeoxyguanosine level of patients with ovulatory infertility and their sex hormones levels in the occurrence of dysfunctive ovarian reserve of the patients |
| 1. Yantai Mountain Hospital, Yantai, Shandong Province, 264000 |
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Abstract To explore the serum 8-hydroxydeoxyguanosine (8-OHdG) expression of patients with ovulatory infertility on their dysfunctive ovarian reserve (DOR), and to analyze the the interaction between the serum 8-OHdG of the patients and their sex hormones levels in the occurrence of dysfunctive ovarian reserve. Methods: The clinical data of 121 patients with ovulatory infertility from June 2019 to January 2022 were collected retrospectively. Based on the DOR occurrence or not, these patients were divided in group A (patients with DOR) and group B (patients without DOR). Logistic regression models were used to evaluate the multiplicative and additive interactions between the serum 8-OHdG expression of the patients with ovulatory infertility and their sex hormones levels. Results: Among the 121 patients, there were 65 (53.7%) cases in group A. There were significantly differences in the levels of serum expressions of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and 8-OHdG of the patients between the two groups (P<0.05). There was no multiplicative interaction between the serum 8-OHdG expression of the patients and their sex hormones levels (P＞0.05). There was a synergistic additive interaction between the serum 8-OHdG expression of the patients and their E2 level (relative over risk ratio=1.539, 95%CI 1.129-1.950). Conclusion: The interaction between serum 8-OHdG expression of patients with ovulatory infertility and their sex hormones levels increases the risk of their DOR occurrence, and so it is suggest that regulating the sex hormones levels of the patients is beneficial for improving their ovarian function.
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