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| Correlation between the serum thyroid function, the placental growth factor, and the hematocrit levels of pregnant women with preeclampsia and their fetal growth restriction |
| Fuyang People's Hospital, Anhui Province, 236000 |
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Abstract To investigate the correlation between the thyroid function, the serum placental growth factor (PLGF), and the hematocrit (HCT) levels of pregnant women with preeclampsia (PE) and their fetal growth restriction (FGR). Methods: 108 pregnant women with PE admitted and delivered in hospital were selected in study group from June 2020 to December 2021. Among them, 42 cases with FGR were in group A and 66 cases without FGR were in group B. 55 normal pregnant women were selected in group C during the same period. The serum levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPO-Ab), PLGF, and HCT of the women in the three groups were measured by immunoassay, and the correlation between which and the FGR occurrence of the women was analyzed. Results: The incidence of the thyroid dysfunction of the women in group C, in group B, and in group A had increased gradually, and the serum levels of TSH, FT4, PLGF, and HCT of the women had significant differences among the three groups (all P<0.05). There was no significant difference in the TPO-Ab level of the women among the three groups (P＞0.05). The serum TSH and HCT levels of the women in group C, in group B, and in group A had increased gradually, while the FT4 level of the women in group C, in group B, and in group A had decreased gradually (all P<0.05). Further logistic regression analysis showed that the thyroid dysfunction, the decreased serum PLGF level, and the HCT level ≥0.35 of the women with PE were the independent risk factors of their FGR occurrence (P<0.05). Conclusion: The abnormal thyroid function changes and the serum PLGF and HCT levels of the pregnant women with PE are the risk factors of their FGR occurrence, and which should be paid more attention to in clinic.
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