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| Value of the vascular microcirculation parameters at the scar site of uterus combined with the endometrial tolerance markers of women for diagnosing their early scar pregnancy |
| Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, 100026 |
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Abstract To investigate the value of the vascular microcirculation parameters at the scar site of uterus combined with the endometrial tolerance markers of women for diagnosing their early cesarean scar pregnancy (CSP). Methods: 116 women with CSP from March 2020 to May 2022 were selected in study group retrospectively, and 80 women with normal early pregnancy after cesarean section were selected in control group during the same period. The values of vascular microcirculation parameters in scar sites, such as vascularized flow index (VFI), vascularized index (VI), and blood flow index (FI), and the levels of endometrial receptivity indexes, such as integrin β3 and leukocytosis inhibitor factor (LIF) of the women were compared between the two. Results: The levels of endometrial receptivity indexes, such as integrin β3 (64.3±12.5 ng/ml) and LIF (6.8±1.3 ng/ml) of the women in the study group were significantly lower than those (86.1±15.9 ng/ml and 8.2±2.8 ng/ml) of the women in the control group. The values of vascular microcirculation parameters of scar site of the women in the study group were significantly higher than those of the women in the control group (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the AUC of the VI value, FI value, VFI value, integrin β3 level, LIF level, and the combination of the VI, FI, and VFI values, and the integrin β3 and LIF levels of the women for diagnosing their early CSP were 0.728, 0.761, 0.811, 0.772, 0.733, and 0.921, respectively. Conclusion: The combination of the vascular microcirculation parameters at the scar site combined with the endometrial tolerance markers levels of the women has some value for diagnosing their early CSP.
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