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Value of the uterine artery Doppler parameters combined with the levels of serum angiopoietin-2 and cyclooxygenase-2 of women for diagnosing their endometriosis |
| 1.Mengcheng First People's Hospital, Bozhou，Anhui Province，233500；2.The First Affiliated Hospital of Bengbu Medical College, Bengbu，Anhui Province |
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Abstract To observe the value of the uterine artery Doppler parameters combined with the levels of serum angiopoietin-2 (Ang-2) and cyclooxygenase-2 (COX-2) of women for diagnosing their endometriosis (EMS). Methods: 86 women with EMS were selected in study group, and 86 women with gynecological benign diseases and without EMS were selected in control group from February 2019 to December 2021. Color Doppler ultrasonography was performed for the women in the two groups to measure their uterine artery Doppler parameters, such as end-diastolic velocity (EDV), peak systolic velocity (PSV), pulsatility index (PI), and resistance index (RI). The serum Ang-2 and COX-2 levels of the women in the two groups were detected. Receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic values of the uterine artery Doppler parameters, and the levels of the serum Ang-2 and COX-2 of the women for their EMS. The correlation between the uterine artery Doppler parameters and the levels of the serum Ang-2 and COX-2 of the women with different stage of EMS and their clinical EMS stages was observed. Results: The values of EDV and PSV of the women in the study group were significantly lower than those of the women in the control group. The values of PI and RI and the serum Ang-2 and COX-2 levels of the women in the study group were significantly higher than those of the women in the control group (P<0.05). ROC curve showed that the maximum area under the curve (AUC) of the combination of the values of Doppler parameters and the levels of serum Ang-2 and COX-2 of the women for diagnosing their EMS was 0.983, and the sensitivity and the specificity of which were 96.5% was 96.5%. The values of EDV and PSV of the women with EMS had decreased gradually with their increased clinical stage of EMS, and the serum Ang-2 and COX-2 levels of the women with EMS had increased gradually with their increased clinical stage of EMS (P<0.05). Spearman correlation analysis showed that the values of EDV and PSV of the women with EMS were negatively correlated with their clinical stage of EMS, and the serum Ang-2 and COX-2 levels of the women with EMS were positively correlated with their clinical stage of EMS (all P<0.05). Conclusion: The uterine artery Doppler parameters values combined with the serum Ang-2 and COX-2 levels of the women with EMS are related to their severity of EMS. The combination of the values of Doppler parameters and the levels of serum Ang-2 and COX-2 of the women for diagnosing their EMS has higher efficacy.
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