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| Diagnostic value of the serum intercellular adhesion molecule-1 and Clara cell protein 16 levels of neonates for their respiratory distress syndrome |
| Chengdu Pidu District Maternal and Child Health and Family Planning Service Center (Chengdu Pidu District Maternal and Child Health Hospital), Chengdu, Sichuan Province, 611730 |
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Abstract To investigate the diagnostic value of the serum intercellular adhesion molecule-1 (ICAM-1) and Clara cell protein 16 (CC16) neonates for their respiratory distress syndrome (NRDS). Methods: A total of 98 neonates with NRDS were selected in study group from January 2019 to December 2022, including 37 cases with mild NRDS in group A, 31 cases with moderate NRDS in group B, and 30 cases with severe NRDS in group C. And 60 neonates with non-pulmonary diseases were selected in control group during the same period. The serum ICAM-1 and CC16 levels of all the neonates were detected, and the differences of which of the neonates were compared among these groups. The correlation between the serum ICAM-1 and CC16 levels of the neonates and their ventilator parameters, such as inhaled oxygen concentration (FiO2), and their days of ventilator used was analyzed. The diagnostic efficacy of the levels of ICAM-1 and CC16 of the neonates for their NRDS was evaluated. Results: The levels of serum ICAM-1 (438.89±122.41μg/ml) and CC16 (39.21±8.14 ng/ml) of the neonates in the study group were significantly higher than those (241.55±52.36μg/ml and 11.17±3.69 ng/ml) of the neonates in the control group, and which of the neonates in group A, group B, and group C had increased gradually (P＜0.05). Pearson correlation analysis showed that the serum ICAM-1 and CC16 levels of the neonates in the study group were positively correlated with their FiO2 levels and their days of ventilator used (P＜0.05). Logistic regression analysis showed that the levels of ICAM-1 and CC16 of the neonates in the study group were the independently correlative factors of the neonatal NRDS occurrence (P＜0.05). ROC curve analysis showed that the area under the curve of the serum ICAM-1 level or CC16 level of the neonates for diagnosing their NRDS was 0.791 or 0.850, and which was significantly lower than that (0.920) of the combined serum ICAM-1 and CC16 levels (P＜0.05). Conclusion: The serum ICAM-1 and CC16 levels of the neonates reflect the severity of their NRDS, and which can be used as the markers for diagnosing the neonatal NRDS.
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