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| Efficacy of surgery combined with drospirenone-ethinylestradiol or dinogest for treating patients with ovarian endometriosis and their influence on serum estradiol level and menstrual blood loss |
| Ezhou Central Hospital, Ezhou, Hubei Province, 436000 |
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Abstract To investigate efficacy of surgery combined with both drospirenone-ethinylestradiol and dinogest for treating patients with ovarian endometriosis and their influence on their serum estradiol (E2) level and menstrual volume. Methods: A total of 124 women with endometriosis who had been treated by surgery in hospital from January 2019 to August 2021 were collected retrospectively, including 63 patients with additional treatment of drospirenone-ethinylestradiol tablets in group A and 61 patients with additional treatment of dienogest in group B. The pain degree evaluated by visual analogue scale (VAS), the serum E2 level, and the menstrual volume before and after treatment, and the clinical efficacy of the patients were compared between two groups. Results: The VAS scores of the patients in both groups after treatment had decreased significantly, and which (1.05±0.43 points) of the patients in group B was significantly lower than that (1.65±0.48 points) of the patients in group A (P＜0.05).The serum E2 levels and the menstrual volume score of the patients in both groups after treatment had decreased significantly (P＜0.05), but which of the patients had no significant differences between the two groups (P＞0.05). There was no significant difference in the total effective rate (96.8% vs. 98.4%) of the patients between the two groups (P＞0.05). Conclusion: The surgery combined with both drospirenone-ethinylestradiol and dinogest for treating the patients with endometriosis have better efficacy and have the similar effect, and both of which can effectively reduce the serum E2 and menstrual volume of the patients, but dienogest is superior to drospirenone- ethinylestradiol in terms of alleviating the pain degrees of the patients.
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