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| Correlation between the antimullerian hormone level of infertility women and their estradiol level and the predictive value of the antimullerian hormone level for the pregnancy outcomes of these women after assisted reproduction |
| Yanda Hospital, Langfang, Hebei Province, 065201 |
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Abstract To investigate the correlation between the antimullerian hormone level of infertility women and their estradiol level, and to study the predictive value of the antimullerian hormone (AMH) level for the pregnancy outcomes of these women after assisted reproduction. Methods: 260 infertile women who had been treated by in vitro fertilization and embryo transfer (IVF-ET) from June 2020 to September 2022 were collected retrospectively. These women were divided into two groups based on whether pregnancy or not, including 174 women with pregnancy in group A and 86 women without pregnancy in group B. The general data, the oocytes retrieved situation, the egg acquisition, and the sex hormones and AMH levels of the women were compared between the two groups. The influencing factors of the pregnancy of the women after assisted reproductive treatment were analyzed. The predictive values of the AMH and E2 levels of the women for their pregnancy were also analyzed. Results: There were no significant differences in the age, the body mass index, the age of spouse, the body mass index of spouse, the infertility years, the number of antral follicles, and the number of fertilized eggs of the women between the two groups (P＞0.05). The duration of exogenous gonadotropin used, the total dose of human chonic gonadotropin used, and the numbers of oocytes retrieved of the women in group A were significantly higher than those of the women in group B. The serum FSH, E2, and LH levels of the women in group A were significantly lower than those of the women in group B. Multifactor analysis showed that the longer exogenous gonadotropin used, the higher dose of total exogenous gonadotropin used, the more umber of oocytes retrieved, the higher AMH, FSH, LH, E2 levels, and the lower levels of FSH, T, and P of the women were the protective factors of their pregnancy after assisted reproductive therapy (P＜0.05). The AMH level of the infertility women was negatively correlated with their E2 and LH levels, but was positively correlated with their FSH, T, and P levels (all P＜0.05). The sensitivities of the AMH level, E2 level, and the combined levels of AMH and E2 of the infertility women for predicting their pregnancy after assisted reproductive therapy were 25.3%, 10.3%, and 89.7%, respectively, and the sensitivity of the combined levels of AMH and E2 of the women for predicting their pregnancy had been improved. Conclusion: The AMH and E2 levels of the infertility women have certain value for predicting their pregnancy outcomes after assisted reproductive therapy, and which can be used as the important basis for the adjustment of clinical treatment regimen.
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