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| Correlation between the serum asprosin and Irisin levels of women with gestational diabetes mellitus and their glucolipid metabolism |
| Qingdao Central Hospital Affiliated to Qingdao University, Qingdao Cancer Hospital, Qingdao, Shandong Province, 266042 |
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Abstract To explore the correlation between the serum asprosin and Irisin levels of pregnant women with gestational diabetes mellitus (GDM) and their glucolipid metabolism. Methods: The data of 83 pregnant women with GDM in study group were analyzed retrospectively. 50 healthy pregnant women were included in control group. The general data, the levels of glucolipid metabolism indicators, such as fasting plasma glucose (FPG), 2h postprandial blood glucose (2hPG), glycated hemoglobin (HbAlc), total cholesterol (TC), high/low density lipoprotein cholesterol (H/LDL-C), and triglyceride (TG), and the serum asprosin and Irisin levels of the women were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between the serum asprosin and Irisin levels of the women with GDM and their glucolipid metabolism. Results: There were no significant differences in the age, the body mass index, the gestational weeks, the number of pregnancies, the values of systolic blood pressure and diastolic blood pressure, and the levels of alanine aminotransferase and glutamic oxalic aminotransferase of the women between the two groups (P＞0.05). The fasting insulin level and the insulin resistance index value of the women in the study group were significantly higher than those of the women in the control group, and the islet β cell function index value of the women in the study group was significantly lower. The levels of FPG, 2hPG, HbAlc, TC, TG, LDL-C, and asprosin of the women in the study group were significantly higher than those of the women in the control group, but the serum Irisin level of the women in the study group was significantly lower (all P＜0.05). There was no significant difference in the HDL-C level of the women between the two groups (P＞0.05). Pearson correlation analysis showed that the levels of FPG, 2hPG, HbAlc, TC, TG, and LDL-C of the women with GDM were positively correlated with their serum asprosin level, and which of the women with GDM was negatively correlated with their serum Irisin level (P＜0.05). There was no correlation between the HDL-C level of the women with GDM and their serum asprosin and Irisin levels (P＞0.05). Conclusion: The women with GDM have abnormal high level of serum asprosin and have abnormal low level of serum Irisin. The levels of asprosin and Irisin of the women with GDM are significantly correlated with their glucolipid metabolism, and which can be used as the clinical auxiliary detective indicators.
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