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| Values of transvaginal ultrasound examination combined with the serum anti Mullerian hormone and carbohydrate antigen-125 levels for diagnosing and evaluating the prognosis of the threatened abortion of women during the first trimester of pregnancy |
| Qianjiang Central Hospital of Hubei Province, 433199 |
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Abstract To investigate the values of transvaginal ultrasound examination combined with the serum anti Mullerian hormone (AMH) and carbohydrate antigen-125 (CA125) levels for diagnosing and evaluating the prognosis of the threatened abortion of women during the first trimester of pregnancy. Methods: The clinical data of 248 pregnant women who came to hospital for antenatal examination during the first trimester of pregnancy from June 2019 to June 2022 were selected as the research objects, including 80 cases with normal pregnancy in control group and 168 cases with threatened abortion in study group. According to the outcomes of the threatened abortion, the women in the study were further divided into group A (105 cases with continued pregnancy) and group B (63 cases with abortion). Enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of serum AMH and CA-125 of the women. The values of the ultrasound parameters and the AMH and CA-125 levels of the women for diagnosing and evaluating the prognosis of the women with threatened abortion were analyzed by receiver operator characteristic (ROC) curve. Results: The level of serum CA125 (54.24±12.86 mIU/ml) of the women in group B was significantly higher than that (34.89±9.47 mIU/ml) of the women in group A and that (24.63±6.32 mIU/ml) of the women in the control group. The AMH level (7.75±1.79 μg/L) of the women in group B was significantly lower than that (10.16±3.01 μg/L) of the women in group A and that (11.75±3.32 μg/L) of the women in the control group. The ultrasonic parameters values of intervillous artery flow, such as resistance index (RI), ascending acceleration time (ACT) of systolic branch, and yolk sac diameter of the women in group B were significantly higher than those of the women in group A and in the control group. The values of peak systolic flow velocity (PSV) and the diameter of gestational sac of the women in group B were significantly lower than those of the women in group A and in the control group (all P＜0.05). The area under the curve (AUC) of the parameters values of transvaginal ultrasonography combined with the levels of AMH and CA125 of the pregnant women for diagnosing their threatened abortion and adverse pregnancy outcomes were 0.966 and 0.993, which were significantly higher than those of the parameters values of transvaginal ultrasonography or the levels of AMH and CA125 alone (all P＜0.05). Conclusion: The combination of the levels of AMH and CA125 and the parameters values of transvaginal ultrasonography of the pregnant women for diagnosing their threatened abortion can obviously improve the diagnostic efficacy and the evaluative efficacy of the prognosis of the women.
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