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Abstract To explore the effect of sodium hyaluronate gel combined with estradiol valerate for preventing intrauterine adhesion of women after high-risk abortion, and to study its impact on the levels of inflammatory factors of the women. Methods: A total of 120 women who had undergone the high-risk abortion were selected and randomly divided into two groups (60 cases in each group) from May 2020 to May 2022. The women in the control group were treated with sodium hyaluronate gel, and the women in the study group were treated with sodium hyaluronate gel combined with estradiol valerate. The time of menstruation recovery, the bleeding time, the bleeding volume, the abnormal uterine bleeding rate, the degree of cervical adhesion, the values of serum cervical adhesion indexes, the levels of human vascular endothelial growth factor (VEGF), human transforming growth factor (TGF-β), human laminin (LN), and human fibronectin (FN), the values of hemorheological indexes, such as whole blood viscosity and plasma viscosity, the levels of inflammatory factors, such as interleukin 18 (IL-18) and leukocyte Interleukin-10 (IL-10), and the incidence of adverse reactions of the women were compared between the two groups. Results: The cervical adhesion rate (3.3%) of the women in the study group in the 3rd month after surgery was significantly lower than that (16.7%) of the women in the control group. After treatment, the levels of serum VEGF, TGF-β, LN, FN, and IL-18, and the values of whole blood viscosity and plasma viscosity of the women in both groups had increased significantly, while the IL-10 level of the women in both groups had decreased significantly, and the change ranges of which of the women in the study group were significantly less than those of the women in the control group (all P<0.05). There were no significant differences in the proportion of abnormal uterine bleeding (16.7% vs.25.0%) and the total incidence of adverse reactions (5.0% vs.11.8%) of the women between the two groups (P>0.05). The duration of menstruation (25.1±2.5d), the duration of vaginal bleeding (4.7±0.6d), and the amount of menstrual bleeding (45.7±4.7ml) of the women in the study group were significantly lower than those (28.6±2.9d, 5.1±0.6d, and 48.5±4.9ml) of the women in the control group (all P<0.05). Conclusion: Sodium hyaluronate gel combined with estradiol valerate for treating the women after high-risk abortion can effectively relieve the degree of intrauterine adhesions, abnormal uterine bleeding, and inflammation, and can promote the recovery of the women, and with safety and effectiveness.
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