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| Effects of protamine human islet injection for treating pregnant women with gestational diabetes mellitus on their islet function, and their hemoglobin and Creactive protein levels |
| 1.People's Hospital of Lujiang County, Hefei, Anhui Province, 231500; 2. Anhui Huainan xinhua medical Group Xinhua Hospital |
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Abstract To analyze the effects of protamine human islet injection for treating pregnant women with gestational diabetes mellitus (GDM) on their islet function, and their hemoglobin (HGB) and C-reactive protein (CRP) levels. Methods: A total of 125 pregnant women with GDM were selected and were divided into control group (n=60) and study group (n=60) by random number table method from January 2019 to January 2023. The women in both groups were given treatment of aspartate insulin for 3 months, and the women in the observation group were treated with protamine synthetic human insulin injection for 3 months additionally. The levels of blood glucose, insulin index, HGB, CRP, homocysteine (Hcy), serum cystatin C (Cys C), superoxide dismutase (SOD), and malondialdehyde (MDA), and the pregnancy outcomes of the women before and after treatment were compared between the two groups. Results: The levels of blood glucose indexes of the women in both groups after 1 and 3 months of treatment had decreased significantly, and which of the women in the study group were significantly lower than those of the women in the control group. The fasting insulin (FINS) level and the insulin secretion index (HOMA-B) value of the women in both groups after 1 and 3 months of treatment had increased, but the insulin resistance index (HOMA-IR) value of the women in both groups had decreased significantly, and the change ranges of which of the women in the study group were significantly more than those of the women in the control group. The levels of HGB and CRP of the women in both groups had decreased significantly, and which of the women in the study group were significantly lower than those of the women in the control group. The levels of Hcy, Cys-C, and MDA of the women in both groups had decreased significantly, but the SOD level of the women in both groups had increased significantly, and the change ranges of which of the women in the study group were significantly more than those of the women in the control group (all P<0.05). The rate of adverse pregnancy outcomes (16.7%) of the women in the study group (16.7%) was significantly lower than that (48.3%) of the women in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions (18.3% vs.11.7%) of the women between the two groups (P>0.05). Conclusion: Protamine human islet injection combined with aspartate insulin for treating the pregnant women with GDM can maintain their better blood glucose level, can restore their normal islet function, can reduce the levels of their HGB and CRP, and can improve their serum Hcy, Cys-C, MDA, and SOD levels, but cannot increase their adverse reactions, with less incidence of the adverse pregnancy outcomes.
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