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| Analgesic effect of esketamine used in cesarean section of advanced pregnant women and the analysis of the pregnancy outcomes of the women |
| 1.Linhai Maternal and Child Health Care Hospital, Zhejiang Province, 317099; 2. Obstetrics and Gynecology Hospital Affiliated to Zhejiang University |
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Abstract To investigate the analgesic effect of esketamine used in cesarean section of advanced pregnant women, and to analyze the pregnancy outcomes of the women. Methods: 166 advanced pregnant women who wanted cesarean section were selected and randomly divided into two groups (83 cases in each group) from July 2019 to June 2022. These women in the two groups were given epidural block during cesarean section. The women in the study group were given esketamine additionally, and the women in the control group were given normal saline. The effectiveness of anesthesia, motor block, and the analgesia, the situations of pain and cognitive function, the adverse reactions rate, and the pregnancy outcomes in different analgesic effects of the women were compared between the two groups. Results: The onset time of anesthesia, the time to reach the highest blocking plane, the Bromage rating score, and the exercise recovery time of the women in the study group were significantly lower than those of the women in the control group, while the time of anesthesia maintenance of the women in the study group was significantly higher (P<0.05). The MMSE scores of the women in the two groups at 2h, 4h, and 12h after surgery were significantly lower than those before surgery, but which had no significant difference of the women between the two groups (P>0.05). The VAS scores of the women in the study group were significantly lower than those of the women in the control group at 2h, 4h, and 12h after surgery, and which of the women in the study group were significantly lower than those of the women in the control group (P<0.05). The analgesic effect of the women in the study group was significantly better than that of the women in the control group, and the rate of good anesthesia (97.6%) of the women in the study group was significantly higher than that (84.3%) of the women in the control group (P<0.05), there was no significant difference in the incidence of adverse reactions (18.1% vs. 10.8%) of the women between the two groups (P>0.05). The incidence of adverse pregnancy outcomes (7.3%) of the women with good anesthesia was significantly lower than that (26.7%) of the women with poor anesthesia (P<0.05). Conclusion: Esketamine used in cesarean section of advanced pregnant women can improve their anesthetic effect, promote their recovery of exercise, and can alleviate their postoperative pain, and which will not increase their adverse reactions. Poor anesthetic effect will increase the adverse pregnancy outcomes of the women.
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