To explore the value of the ratio of triglyceride to cystatin C (TG/CysC) of pregnant women with hypertensive disorders complicating pregnancy (HDCP) for predicting their early renal impairment. Methods: A total of 98 pregnant women with HDCP confirmed during antenatal examination from May 2019 to May 2022 were collected in study group retrospectively, and 90 normal pregnant women who came to hospital for prenatal examination were selected in control group during the same period. The levels of serum TG and CysC of the women in the two groups were detected, and the ratio of TG/CysC of the women was calculated. The women in the study group were divided into group A (60 women with normal renal function) and group B (38 women with renal function impairment) according to whether early renal function impairment occurred or not during the follow up. The levels of serum TG and CysC, and the ratio of TG/CysC of the women were compared among these groups. Receiver operating characteristic curve (ROC) was used to evaluate the value of the ratio of TG/CysC of the women with HDCP for predicting their early renal impairment. Results: The ratio of TG/CysC (2.13±0.28) of the women in the study group was significantly lower than that (3.57±0.47) of the women in the control group, and which (1.76±0.22) of the women in group B was significantly lower than that (2.63±0.44) of the women in group A (all P＜0.05). ROC curve analysis showed that the area under the curve, the cutoff value, the sensitivity, the specificity, the positive predictive value, and the negative predictive value of the ratio of TG/CysC of the women with HDCP for predicting their early renal function impairment were 0.921, 2.14, 86.3%, 85.2%, 86.7%, and 85.6%, respectively. Conclusion: The ratio of TG/CysC in peripheral blood of the pregnant women with HDCP decreases, and which of the women with early renal function impairment more decreases. So it can be used as the clinical indicator for predicting the early renal function impairment of with HDCP.