To study the correlation between the  levels of insulin-like growth factor I(IGF I) and II(IGF II), and the venous blood flow changes of pregnant women during the second and the third trimesters of pregnancy and their fetal growth restriction(FGR). Methods: A total of 53 pregnant women with FGR during the second and the third trimesters of pregnancy were enrolled in study group between April 2018 and March 2021, while other 62 healthy pregnant women during the same period were enrolled in control group. The general data of these women were collected. The levels of IGF I and IGF II of the women in the two groups were detected. The fetal venous blood flow parameters in both groups were detected by color Doppler ultrasound. The correlation between the levels of IGF I and IGF II, and the fetal venous blood flow changes of the women and their FGR was analyzed. Results: The IGF Ⅰ and IGF Ⅱ levels in amniotic fluid and the IGF Ⅰlevel in blood of the women in the study group were significantly lower than those of the women in the control group(P＜0.05), there was no significant difference in the IGF Ⅱ level in blood of the women between the two groups(P>0.05). The values of fetal venous blood flow S-wave velocity(S) and A valley velocity(A) of the women in the study group were significantly lower than those of the women in the control group, and the values of resistance index(RI) RI, pulsation index(PI) PI, and systolic to diastolic ratio(S/D) of fetal venous blood flow of the women in the study group were significantly higher than those of the women in the control group(all P＜0.05). Logistic regression analysis showed that the levels of IGF Ⅰ and IGF Ⅱ in amniotic fluid, and the blood flow parameters, such as RI, PI, and S/D of fetal venous blood were the independent risk factors of the development of FGR occurrence(P＜0.05). Pearson correlation analysis showed that the levels of IGF Ⅰand IGF Ⅱ in amniotic fluid were negatively correlated with the values of RI, PI, and S/D of the fetal venous blood(P＜0.05). Receiver operating characteristic(ROC) curve analysis showed that the area under the curve(AUC) and the sensitivity of the levels of IGF Ⅰand IGF Ⅱ in amniotic fluid combined with the values of the fetal venous blood flow parameters, such as RI, PI, and S/D, for predicting their FGR  were 0.964 and 98.1%, which were the highest(P＜0.05). Conclusion: The levels of IGF Ⅰand IGF Ⅱ in amniotic fluid and the values of the fetal venous blood flow parameters changes during the second and the third trimesters of pregnancy are the risk factors of FGR, which should be attained in clinic and can be as the evidences for predicting their FGR early.