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| The chorionicity of twins, the level of serum Krüppel like factor 8, and the neonatal outcomes of pregnant women with early onset preeclampsia |
| Qionghai Hospital of Traditional Chinese Medicine, Qionghai, Hainan Province, 571400 |
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Abstract To investigate the chorionicity of twins, the level of serum Krüppel like factor 8(KLF 8), and the neonatal outcomes of pregnant women with early onset preeclampsia. Methods: The clinical data of 112 women with early onset preeclampsia from January 2020 to January 2022 were enrolled in experimental group, and other healthy pregnant women were included in control group during the same period. The rate of twin chorionicity and the serum KLF 8 level of the women were compared between two groups. The clinical characteristics of the women with different neonatal outcomes and the the risk factor associated with the early onset preeclampsia of the women were analyzed. Results: The incidence of the twins’chorionicity(12.5%) of the women in the experimental group was significantly higher than than that(1.8%) of the women in the control group. The level of serum KLF 8(15.63 ±2.14 pg/ml) of the women in the experimental group was significantly lower than that(36.63±2.04 pg/ml) of the women in the control group. The gestational weeks and the serum KLF 8 level of the women with poor neonatal outcomes in the experimental group were significantly lower than those of the women with normal neonatal outcomes(all P＜0.05). Logistic regression analysis showed that the twins’ chorionicity, the decrease of serum KLF 8 level, the less gestational weeks, the placental abruption, and the eclampsia history of the women were all the independent risk factors of their poor neonatal outcomes(P＜0.05). Conclusion: The twins’ chorionicity and the serum KLF 8 level of the pregnant women may be related to their early onset preeclampsia and neonatal outcomes.
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