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| Application effect of special staining technique of cervical exfoliated cells in the screening of cervical lesions |
| 1.The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450014; 2. National Research Institute for Family Planning, Beijing; 3. Queen Mary College of Nanchang University |
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Abstract To explore the clinical application effect of special staining technique of cervical exfoliated cells in the screening of cervical lesions. Methods: A total of 1176 women who underwent the screening of cervical lesions in several medical centers were selected in this study from March 2021 to June 2022. These women received two cervical cancer screening tests, including human papillomavirus (HPV)combined with thinprep cytologic test (TCT)and special staining technique of cervical exfoliated cells for cervical exfoliated cells. Based on the pathological results of cervical biopsy as the gold standard, the comparative analysis of clinical application effect of the HPV, TCT, and special staining technique of cervical exfoliated cells in the screening of cervical lesions was conducted. Results: The consistent rate of the positive cases detected by TCT (40.1%), by special staining technique of cervical exfoliated cells (28.8%), and by HPV (19.6%)had decreased gradually (P＜0.05). There were no significant differences in the sensitivity (62.1% vs. 53.8%)and the accuracy (80.1% vs. 89.8%)for screening cervical lesions between the special staining technique of cervical exfoliated cells and TCT (P＞0.05). Conclusion: The sensitivity and the accuracy of special staining test of cervical exfoliated cells for screening of cervical lesions are equivalent to those of TCT. Special staining test of cervical exfoliated cells has the characteristics of high portability, simple operation, rapid detection, and economy and practicality, etc, and which as a cervical cancer screening technology is suitable for implementation by the primary level health service agencies.
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