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Abstract To explore the diagnostic value of the combined detections of serum carbohydrate antigen 72-4 (CA72-4), carbohydrate antigen 15-3 (CA15-3), and ferritin (SF)of women for diagnosing their cervical cancer (CC)early. Methods: From October 2019 to September 2022, 75 women with cervical intraepithelial neoplasia (CIN)were selected in group A, 80 women with CC were selected in group B, and 80 healthy women were selected in group C. The levels of serum CA72-4, CA15-3, SF, and carbohydrate antigen 125 (CA125)of the women were compared among the three groups. The correlation between the serum CA72-4, CA153, and SF levels of the women with CC and their clinicopathological characteristics was analyzed. The early diagnostic value of the levels of serum CA72-4, CA15-3, SF, and CA12-5 of the women for their CC was analyzed. The influencing factors of CC occurrence of the women were also analyzed. Results: The levels of serum CA72-4, CA15-3, SF, and CA12-5 of the women in group C, in group A, and in group B had increased gradually (P＜0.05). The levels of serum CA72-4, CA15-3, and SF of the women with low differentiated CC were significantly higher than those of the women with highly differentiated CC (P＜0.05). The area under curve (AUC)of serum CA72-4 level, CA15-3 level, SF level, and CA12-5 level of the women for diagnosing their CC were 0.843, 0.866, 0.870, and 0.894, respectively. The AUC, the sensitivity, and the specificity of the combined levels of CA72-4, CA15-3, and SF of the women for diagnosing their CC were 0.961, 95.0%, and 86.7%, respectively. The elevated levels of serum CA72-4, CA15-3, SF, and CA12-5 of the women were the influencing factors of their early CC development (P＜0.05). Conclusion: The incidence of the levels of serum CA72-4, CA15-3, and SF of the women with early CC is higher. The levels of serum CA72-4, CA15-3, and SF of the women can assist in the diagnosis of early CC, and the combinations of CA72-4, CA15-3 and SF has higher diagnostic value for early CC, which may be more helpful for clinical screening of the women with CC early.
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