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| Expression levels of serum folate-receptor 1 and mesothelin of women with endometriosis and their correlation with the clinical symptoms |
| 1.Xinmi City Maternal and Child Health Care Hospital, Henan Province, 450000；2. Zhengzhou Central Hospital, Henan Province |
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Abstract To explorethe expression levels of serum folate-receptor 1/alpha (FOLR1)and mesothelin (MSLN)of women with endometriosis (EMs), and to study their correlation with the clinical symptoms of the women. Methods: A total of 96 women with EMs were selected in group A, and were divided into group A1 (22 cases with stage I of EMs), group A2 (30 cases with stage II of EMs), group A3 (26 cases with stage III of EMs), and group A4 (18 cases with stage IV of EMs)according to r-AFS staging from May 2018 to May 2021. 80 healthy women with similar age were selected in group B during the same period. The levels of serum FOLR1 and MSLN of the women in the two groups were detected by enzyme-related immunosorbent assay, and the differences of which of the women were compared among these groups. Receiver operating characteristic curve (ROC)was drawn to determine the cut-off values of the levels of serum FOLR1 and MSLN of the women for diagnosing their EMs, and Pearson correlation was used to analyze the correlation between the levels of serum FOLR1 and MSLN of the women with Ems and their clinical symptoms. Results: The levels of serum FOLR1 (365.20±80.41 pg/ml)and MSLN (10.36±2.33μg/L)of the women in group A were significantly lower than those (113.25±30.36 pg/ml and 3.25±0.66μg/L)of the women in the control group, and which of the women in group A1, in group A2, in group A3, and in group A4 of the women had increased gradually (all P＜0.05). ROC curve analysis showed that the cut-off values of the levels of serum FOLR1 and MSLN of the women for diagnosing their EMs were 230.22pg/ml and 6.52μg/L. According to the cut-off values of the levels of serum FOLR1 and MSLN, the women in group A were divided into group A5 (women with high levels of FOLR1 and MSLN)and group A6 (women with low levels of FOLR1 and MSLN). The scores of clinical symptom, such as dysmenorrhea, pelvic pain, coital pain, and anal bulge of the women in group A5 were significantly higher than those of the women in group A6 (P＜0.05). The levels of serum FOLR1 and MSLN of the women in group A were positively correlated with their clinical symptoms (r=0.421, 0.388, all P＜0.05). Conclusion: The levels of serum FOLR1 and MSLN of the women with EMs increase abnormally, and the changes of which are positively correlated with the clinical of these women.
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