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| Changes of the levels of hypoxia inducible factor-1α, angiopoietin-1， and p53 protein in gestational trophoblastic disease tissues and their predictive efficacy for the malignant transformation of hydatidiform mole |
| Yuncheng Central Hospital, Yuncheng, Shanxi Province, 044000 |
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Abstract To study the changes of the levels of hypoxia inducible factor-1α(HIF-1α), angiopoietin-1 (ANG-1), and p53 protein levels in gestational trophoblastic disease tissues of women, and to study their predictive efficacy for the malignant transformation of hydatidiform mole of the women. Methods: 88 women with gestational trophoblastic disease diagnosed and treated in hospital were selected in study group, and 88 normal pregnant women with abortion and curettage during early pregnancy were selected in control group from January 2018 to January 2021. The levels of HIF-1α, ANG-1, and p53 protein in gestational trophoblastic disease tissues of the women were compared between the two groups, and the predictive efficacy of which for the malignant transformation of hydatidiform mole of the women was analyzed. Results: The relative expression levels of HIF-1α, ANG-1, and p53 protein of the women in the study group were significantly higher than those of the women in the control group. The expressions levels of HIF-1α, ANG-1, and p53 protein in choriocarcinoma tissue, in invasive hydatidiform mole tissue, and in hydatidiform mole tissue of the women in the study group had significantly different (all P＜0.05). The specificity of the combined levels of HIF1α, ANG-1, and p53 protein of the women for diagnosing their choriocarcinoma or invasive hydatidiform mole was 58.1% or 54.8%, which was significantly higher than that of HIF-1αlevel, ANG-1 level, or p53 protein level alone. The areas under receiver operating characteristic (ROC)curve of the levels of HIF-1α, ANG-1, and p53 protein of the women for diagnosing their invasive hydatidiform mole and choriocarcinoma were 0.909 and 0.998. The critical values of HIF1αlevel, ANG-1 level, and p53 protein level of the women for diagnosing their invasive hydatidiform mole or choriocarcinoma were 1.88 or 2.91, 2.61 or 2.89, and 3.77 or 3.30, respectively. Conclusion: The changes of HIF-1α, ANG-1, and p53 protein levels in gestational trophoblastic disease tissues of the women are abnormal, and the combined detections of HIF-1α, ANG-1, and p53 protein levels of the women have certain predictive value for the malignant transformation of hydatidiform mole of the women.
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