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| Effect of thunder fire moxibustion combined with Guizhi fuling pills for treating patients with chronic pelvic inflammatory disease and its influence on the TGF-β1/Smads pathway |
| 1.Xinwu District Xinrui Hospital, Wuxi, Jiangsu Province, 214000；2.Tongji Hospital of Shanghai |
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Abstract To explore the clinical effect of thunder fire moxibustion combined with Guizhi fuling pills for treating patients with chronic pelvic inflammatory disease (CPID), and to study its influence on the transforming growth factor-β1/drosophila mothers against decapentaplegic protein (TGF-β1/Smads)pathway of the patients. Methods: 102 patients with CPID were selected and were divided into two groups according to the random number table method from February 2019 to February 2021. 51 patients in the control group received treatment of metronidazole combined with evofloxacin, and 51 patients in the observation group were treated with thunder fire moxibustion combined with Guizhi fuling pills except to the treatment of the patients in the control group. The scores of TCM symptoms, such as primary symptom, secondary symptom, and local signs, the levels of TGF-β1/Smads pathway, such as TGF-β1,Smad2, and Smad3, the levels of mediators, such as erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor α(TNF-α), the values of hemorheology, such as high-cut whole blood viscosity, low-cut whole blood viscosity, plasma viscosity, and hematocrit, and the values of imaging indicators, such as enlarged attachments, pelvic fluid, and pelvic mass, of the patients before and after treatment were analyzed and compared between the two groups. The clinical efficacy and safety of the patients in the two groups after treatment were also analyzed and compared. Results: The quantitative scores of main symptoms, secondary symptoms, and local signs of the patients in both groups after treatment had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group. The levels of TGF-β1 mRNA, Smad2 mRNA, Smad3 mRNA, ESR, hs-CRP, and TNF-α, and the values of whole blood viscosity high cut, whole blood viscosity low cut, plasma viscosity, and erythrocyte ratio of the patients in both groups had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group. B-ultrasound examination after treatment showed that the proportions of the thickened appendages, pelvic effusion, and pelvic mass of the patients in both groups had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group (all P＜0.05). The total effective rate (92.2%)of the patients in the observation group was significantly higher than that (76.5%)of the patients in the control group (P＜0.05), and there was no significant difference in the adverse reaction (13.7% vs.11.8%)of the patients between the two groups (P＞0.05). Conclusion: Thunder fire moxibustion combined with Guizhi fuling pills for treating the patients with CPID can inhibit their TGF-β1/Smads pathway, reduce their symptoms and body inflammation, improve their blood rheology and imaging indicators, and which has higher efficacy, with safety and reliability.
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