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| Improvement effect of the metabolic disorders and the ovarian hemodynamics of patients with polycystic ovary syndrome treated by Erxian decoction combined with Guizhi fuling pills modifications |
| 1.Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, 230000；2.Tongcheng Traditional Chinese Medicine Hospital, Tongcheng, Anhui Province；3. The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei; 4. Lu'an Traditional Chinese Medicine Hospital, Anhui Province |
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Abstract To observe the effect of Erxian decoction combined with Guizhi fuling pills modifications for treating patients with polycystic ovary syndrome (PCOS), and to study its influence on the metabolic disorders and the ovarian hemodynamics of the patients. Methods: 104 patients with PCOS who visited the hospital and had been treated with Ethinylestradiol cyproterone acetate tablets were randomly divided into two groups (52 cases in each group) from March 2021 to March 2023. The patients in the observation group were treated with Erxian decoction combined with Guizhi fuling pills modifications additionally. The therapeutic effect of the patients in the two groups after three menstrual cycles of treatment was evaluated. The serum sex hormones and the metabolic indicators of the patients in the two groups were detected. The values of peak systolic blood flow velocity (PSV), resistance index (RI) and end diastolic blood flow velocity (EDV) of ovarian interstitial artery of the patients in the two groups were measured by ultrasound. Results: After treatment, the TCM syndrome score (5.58±1.89 points), the serum testosterone level (2.01±0.33 nmol/L), the fasting blood glucose level (4.65±0.37 mmol/L), the luteinizing hormone level (7.12±0.64 U/L), the total cholesterol level (4.11±0.32) mmol/L, the ratio of luteinizing hormone/follicle stimulating hormone (1.31±0.12), the low density lipoprotein cholesterol level (2.46±0.31 mmol/L), the fasting insulin (11.07±2.65) and the triglyceride level (1.09±0.19 mmol/L) of the patients in the observation group were significantly lower than those (7.96±2.03 points, 2.74±0.42 nmol/L, 5.22±0.51 mmol/L, 9.34±0.85 U/L, 4.52±0.36 mmol/L, 1.72±0.21, 2.67±0.43 mmol/L, 12.89±2.97 and 1.23±0.21 mmol/L) of the patients in the control group, and the level of estradiol (68.85±5.96 ng/L) of the patients in the observation group was significantly higher than that (62.48±5.17 ng/L) of the patients in the control group (all P<0.05). There was no significant difference in the levels of follicle stimulating hormone and highdensity lipoprotein cholesterol of the patients between the two groups (P>0.05). The values of ovarian PSV (12.21±1.98 cm/s) and EDV (10.02±2.17 cm/s) of the patients in the observation group were significantly lower than those (15.88±2.01 cm/s and 11.53±2.25 cm/s) of the patients in the control group. The RI value (0.82±0.21) and the total effective rate (98.1%) of the patients in the observation group were significantly higher than those (0.62±0.13 and 84.6%) of the patients in the control group (all P<0.05). Conclusion: Erxian decoction combined with Guizhi fuling pills modifications for treating the patients with PCOS can improve their clinical symptoms, correct their endocrine and glucose lipid metabolism disorders, improve their ovarian hemodynamics and enhance their clinical efficacy.
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