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| Expressions and clinical significances of microtubule associated protein light chain 3, Beclin1, and high mobility group protein B1 in placenta tissue of pregnant women with placenta previa and placenta implantation |
| The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450000 |
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Abstract To investigate the expressions and clinical significances of microtubule associated protein light chain 3 (LC3), Beclin1, and high mobility group protein B1 (HMGB1) in placenta tissue of pregnant women with placenta previa and placenta implantation. Methods: 96 pregnant women with placenta previa were included in group A and 75 healthy pregnant women with cesarean delivery were included in group B from January 2019 to December 2020. The expression levels of LC3, Beclin1, and HMGB1 in the placenta tissues of the women in the two groups were detected. The women in group A were further divided into group A1 (women with placenta implantation) and group A2 (women without placenta implantation), thereafter, the risk factors affecting the occurrence of placenta implantation were explored. Results: There was no significant difference in the age of the women between group A and group B. The gestational weeks when delivery of the women in group A was significantly less than that of the women in group B, and the gravidity number, the parity number, the number of previous cesarean section, and the time from last cesarean section to this pregnancy of the women in group A were significantly higher than those of the women in group B (P＜0.05). There were 42 (43.8%) cases in group A1 and 54 (56.3%) in group A2. There were no significant differences in the age, the gestational weeks when delivery, and the gravidity of the women between group A1 and group A2. There were significant differences in the parity number, the number of previous cesarean section, the time from last cesarean section to this pregnancy, the previa type, the placenta position, and the expression levels of LC3, Beclin1, and HMGB1 of the women between group A1 and group A2 (P＜0.05). The expression levels of LC3 (1.03±0.13), Beclin1 (1.58±0.43), and HMGB1 (1.67±0.29) in placental tissue of the women in group A were significantly higher than those (1.06±0.12, 1.07±0.12, and 0.68±0.09) of the women in group B. The expression levels of LC3, Beclin1, and HMGB1 (1.93±0.37, 1.72±0.52, and 1.13±0.15) of the women in group A1 significantly higher than those (1.46±0.34, 1.39±0.40, and 1.13±0.15) of the women in group A2 (all P＜0.05). Multiple logistic analysis showed that the factors affecting the occurrence of placenta previa of the pregnant women included the gestational weeks, the gravidity number, the parity number, the number of previous cesarean section, the time from last cesarean section to this pregnancy, and the levels of LC3, Beclin1, and HMGB1. The factors affecting the occurrence of placenta implantation of the women with placenta previa included the parity number, the number of previous cesarean section, the time interval since last cesarean section, the type of placenta previa, the placenta location, and the expression levels of LC3, Beclin1, and HMGB1. Conclusion: The expressions of LC3, Beclin1, and HMGB1 proteins in placenta tissues of the women with placenta previa increase, and which of the women with placenta previa complicating placenta implantation are higher. The high expressions of LC3, Beclin1, and HMGB1 of the women are the risk factors of their development of placenta previa and placenta implantation.
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