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| Effects of different dosage of nalbuphine combined with sufentanil used in uterine myomectomy of patients on their pain mediators and hemodynamics |
| Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210000 |
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Abstract To investigate the effects of different dosage of nalbuphine combined with sufentanil used in laparoscopic uterine myomectomy of patients on their pain mediators and hemodynamics. Methods: 102 patients who wanted laparoscopic uterine myomectomy were randomly selected and were divided into group A, group B, and group C (34 cases in each group) according to the random number table method from April 2019 to April 2022. All the patients in the three groups were given sufentanil induction anesthesia, and then the patients in group A, group B, and group C were given 0.15mg/kg, 0.25mg/kg, and 0.35mg/kg nalbuphine injection after the operation, respectively. The hemodynamic indexes and the pain medium indexes, such as the levels of substance P and prostaglandin E2 (PGE2), of the patients in the three groups before operation, at the time of injection of nalbuphine, and in the 6th hour after operation were recorded. The clinical operation indexes, the pain medium indexes, the hemodynamic indexes, the pain score by VAS, the sedation score (Ramsay), and the rate of adverse reactions of the patients were compared among the three groups. Results: The operation time and the sufentanil dosage of the patients had no significant differences among the three groups. The extubation time of the patients in group B (9.6±2.1min) was significantly less than that (12.2±2.3min) of the patients in group A and that (11.3±2.6min) of the patients in group C. There were significant differences in the values of mean arterial pressure and heart rate, and the levels of serum substance P and PGE2 of the patients among the three groups. The VAS scores of the patients at postoperative 24h in group A, in group B, and in group C were 3.18±0.46 points, 2.15±0.56 points, and 2.06±0.49 points, respectively, which had decreased gradually. The highest score of Ramsay of the patients in group A, in group B, and in group C were 1.59±0.61 points, 1.97±0.52 points, and 2.47±0.51 points, which had increased gradually. The incidence of adverse reactions (23.5%) of the patients in group C was significantly higher than that (2.9%) of the patients in group B and that (8.8%) of the patients in group A (all P＜0.05). Conclusion: Overall consideration, 0.25mg/kg nalbuphine combined with sufentanil can play a better analgesic effect during the uterine myomectomy of the patients, and which can significantly improve the pain medium and hemodynamic level of these patients, with low adverse reactions and guaranteed safety.
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