To analyze the changing trend and spatial distribution pattern of premarital medical examination rate in my country from 2005 to 2020, and provide reference for further improving the quality of marriage and childbirth and the quality of birth population. Methods：The trend of premarital medical examination rate in my country was descriptively analyzed, and the spatial distribution pattern of Level of premarital examination in my country was analyzed by spatial autocorrelation analysis. Results：From 2005 to 2020, the rate of premarital check-ups increased from 2.9% to 68.4%, the number of detected diseases increased from 38,958 to 783,337, and the rate of detected diseases decreased from 10.19% to 8.57%. The high-low heterogenous region of marital examination rate increased by one and only Sichuan Province, the low-high heterogenous region changed from Qinghai to Tibet, the high-high aggregation region changed from Xinjiang to Anhui, and the low-low aggregation region no longer exists. Conclusions：Since 2005,the rate of national marriage examination increases year by year, but the overall growth is slow; The number of detected diseases increased and the rate of detected diseases decreased;The overall aggregation of marital examination level was not significant, but the aggregation trend in local areas was moderate.