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| Clinical value of p16/ki 67 dual stained cytology of high-risk human papilloma virus for screening cervical cancer |
| Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui Province，230000 |
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Abstract To explore the clinical values of the type of high-risk human papilloma virus (HR-HPV), thinprep cytologic test (TCT), and P16/Ki 67 dual stained cytology for screening cervical cancer. Methods: The results of HR-HPV, TCT, P16/Ki 67 dual stained cytology, and colposcopy of 98 patients from June 2018 to June 2020 were collected retrospectively, and the consistency between which and the pathological results of cervical biopsy of these patients were compared. Results：The positive rates of P16/Ki 67 dual stained cytology and TCT had increased gradually as the aggravation of cervical lesions of the patients (all P＜0.05). The positive rates of P16/Ki 67 dual stained cytology (72.3%) of the patients with HPV16/18 infection was significantly higher than that (34.3%) of the patients with other 12 types of HPV infection. The sensitivity of HPV, TCT, and P16/Ki 67 dual stained cytology for diagnosing HSIL+ of the patients were 94.3%, 62.3%, and 81.1%, respectively, and the specificity of which were 29.0%, 71.1%, and 84.4%, respectively. The highest accuracy, the sensitivity, and the specificity of P16/Ki 67 dual stained cytology, 67+HR, and HPV+TCT for diagnosing HSIL+ of the patients were 86.7%, 88.9%, and 84.9%, respectively. Conclusion: The combined detection of HR-HPV, TCT, and P16/Ki 67 dual stained cytology of the patients can increase the accuracy of their cervical cancer screening, and reduce their missed diagnosis rate of cervical lesions and their referral rate to colposcopy, which can provide the guidance for shunting management in clinic.
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