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| Effects of the incubation period of delivery, the timing of termination, and the mode of delivery of pregnant women with preterm premature rupture of membranes on their pregnancy outcomes |
| 1. Huangshan City people's Hospital, Huangshan, Anhui Province, 238000; 2.The First Affiliated Hospital of University of Science and Technology of China，Hefei |
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Abstract To investigate the effects of the incubation period of delivery, the timing of termination, and the mode of delivery of pregnant women with preterm premature rupture of membranes (PPROM) on their pregnancy outcomes. Methods: The clinical data of 267 pregnant women with PPROM (in 35-36 gestational weeks) from January 2017 to June 2020 were analyzed retrospectively. According to the incubation period of delivery < 24h or ≥ 24h and the treatment scheme, these women were divided into three groups, which included 52 women without treatment in 24h after membrane rupture and waiting for natural delivery in group A, 138 women without uterine contraction within 24 hours after rupture of membranes were given oxytocin intravenous drip to induce delivery in group B, and 77 women who had been given ritodrine or magnesium sulfate intravenously after membrane rupture to inhibit uterine contraction and protect the fetus until delivery in group C. The pregnancy outcomes (cesarean section rate), and the maternal and infant complications, such as intrauterine infection rate, puerperal infection rate, postpartum hemorrhage rate, neonatal respiratory distress syndrome, and perinatal death rate of the women were compared among the three groups. Results: 80(30.0%) women in 267 women with PPROM had terminated their pregnancy by cesarean section. The cesarean section rate (59.7%) of the women in group C was significantly higher than that (16.7%) of the women in group B or that (21.2%) of the women in group A. The rates of intrauterine infection (26.0%) and puerperal disease (23.4) of the women in group C were significantly higher than those (7.2% and 5.8%) of the women in group B or those (5.1% and 3.9%) of the women in group A (all P＜0.05). There was no significant difference in the incidence of maternal and infant complications of the women among the three groups (P＞0.05). Conclusion: The mature fetus (≥34 gestational week) of the pregnant women with PPROM and within 24h after membrane rupture should be consider terminating pregnancy in time, and their mode of delivery should be determined according to obstetric routine, so as to obtain the good pregnancy outcomes.
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