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| Effects of 0.2mg/kg of esketamine for anesthesia induction during hysteroscopic surgery of women on their haemodynamics |
| Nanjing Tongren Hospital, Affiliated to Southeast University Medical College, Nanjing, Jiangsu Province, 21110 |
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Abstract To investigate the effects of sub-anesthetic dose of esketamine for anesthesia induction during hysteroscopic surgery of women on their haemodynamics. Methods: A total of 82 women who wanted hysteroscopic surgery were selected and were randomly divided into two groups (41 cases in each group) from June 2021 to March 2022. The women in both groups were given anesthesia induction by sufentanil 0.1μg/kg and etomidate 0.2mg/kg. The women in the observation group were given 0.2mg/kg esketamine additionally, while the women in the control group were given 0.2mg/kg sodium chloride solution additionally. The values of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure, and blood oxygen saturation (SpO2), and the levels of blood glucose and arterial lactic acid of the women in the two groups were counted. The anesthetic effect and adverse reactions rate of the women were compared between the two groups. Results: The values of HR, SBP, DBP, and SpO2 of the women before induction of anesthesia (T1) and immediately after awakening (T4) had no significantly different between the two groups, but which of the women in the observation group immediately before entry laryngoscope (T2) and at the end of examination (T3) were significantly higher than those of the women in the control group (all P＜0.05). There were no significant differences in the levels of epinephrine and norepinephrine of the women at each test point between the two groups (P＞0.05). The levels of epinephrine and norepinephrine of the women in the two groups at T2 and T3 were significantly higher than those at T1 (P＜0.05), and which of the women in the two groups had no significant difference between at T4 and at T1 (P＞0.05). The blood glucose level of the women in the two groups after induction of anesthesia had increased significantly, and which of the women in the observation group was significantly lower than that of the women in the control group. The lactic acid level of the women in the two groups had decreased significantly after induction of anesthesia (P＜0.05). The effective rate of anesthesia (100%) of the women in the observation group was significantly higher than that (87.8%) of the women in the control group (P＜0.05), and the total incidence of adverse reactions (2.4% vs.7.3%) of the women had no significant difference between the two groups (P＞0.05). Conclusion: 0.2mg/kg of esketamine is helpful to stabilize the hemodynamics of the women during hysteroscopic surgery, with good anesthetic effect and safety.
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