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| Effects of combined spinal-epidural anesthesia assisted by dexmedetomidine during cesarean section of women on their anesthesia quality and stress indexes |
| 1. Henan university of Science and Technology, Luoyang, Henan Province, 471003；2. No.989 Hospital of Joint Logistic Support Force, Luoyang |
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Abstract To explore the effects of combined spinal-epidural anesthesia assisted by dexmedetomidine during cesarean section of women on their anesthesia quality and their stress indexes. Methods: A total of 106 pregnant women who wanted elective cesarean section were selected and were divided into two groups (53 cases in each group) by random number table from January 2019 to January 2021. The women in both groups were given combined spinal-epidural anesthesia with 0.75% ropivacaine intrathecally. On this basis, the women in the observation group were also given dexmedetomidine additionally, and the women in the control group were given the same amount of normal saline. The anesthesia quality, the adverse reactions rate, and the stress response indicators levels of the women were compared between the two groups. Results: The onset time of nerve block (3.44±0.69), the time to the maximum anesthesia plane (10.12±1.36), the onset time of motor block (3.19±0.62), and the time to Bromage maximum score (12.82±2.11) of the women in the observation group had significantly different from those (5.26±0.84, 12.81±1.45, 4.77±0.71, and 15.64±2.57) of the women in the control group (P＜0.05). The sedation Ramsay score of the women at T0 had no significant difference between the two groups (P＞0.05), but which of the women in the observation group at T1, T2, or T3 was significantly higher than that of the women in the control group (P＜0.05). The levels of serum Cor, SOD, MDA, ROS, ET, and AngⅡ of the women at T0 had no significant difference between the two groups (P＞0.05). The levels of serum Cor, MDA, ROS, ET, and AngⅡ of the women in the observation group at T1 or T4 were significantly lower than those of the women in the control group, but the SOD level of the women in the observation group was significantly higher than that of the women in the control group. The levels of serum Cor, SOD, MDA, ROS, ET, and AngⅡ of the women in the observation group at T1 or T4 were significantly higher than those at T0, and which at T4 were significantly lower than those at T1 (P＜0.05). The incidence of chills (3.8%) of the women in the observation group was significantly lower than that (20.8%) of the women in the control group (P＜0.05). There were no significant differences in the incidences of adverse reactions, such as nausea and vomiting, bradycardia, dizziness, headache, hypotension, and pruritus, of the women between the two groups (P＞0.05). Conclusion: Dexmedetomidine assisted combined spinal-epidural anesthesia during cesarean section of the women is conducive to improving their anesthesia quality and sedative effect, and to reduce their incidence of adverse reactions with less influence on their stress indexes, which can reduce the stress response of these women.
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